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Article

Light-Activated Liposomes Coated with Hyaluronic Acid as a Potential Drug Delivery System

1
Drug Research Program, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5 E, FI-00790 Helsinki, Finland
2
Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, P.O. Box 80.082, 3508 TB Utrecht, The Netherlands
3
Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5 E, FI-00790 Helsinki, Finland
4
Human Microbiome Research, Faculty of Medicine, University of Helsinki, Haartmaninkatu 3, FI-00290 Helsinki, Finland
5
Institute of Environmental Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden
6
School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Yliopistonranta 1, 70210 Kuopio, Finland
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Institute of Chemistry, St. Petersburg State University, Petergof, Universitetskii pr. 26, 198504 St. Petersburg, Russia
8
Laboratory of Pharmaceutical Technology, Department of Pharmaceutical Science, Tokyo University of Pharmacy & Life Sciences, 1432-1 Hachioji, Tokyo 192-0392, Japan
*
Author to whom correspondence should be addressed.
Pharmaceutics 2020, 12(8), 763; https://doi.org/10.3390/pharmaceutics12080763
Received: 6 July 2020 / Revised: 5 August 2020 / Accepted: 9 August 2020 / Published: 12 August 2020
(This article belongs to the Special Issue Preclinical Evaluation of Lipid-Based Nanosystems)
Light-activated liposomes permit site and time-specific drug delivery to ocular and systemic targets. We combined a light activation technology based on indocyanine green with a hyaluronic acid (HA) coating by synthesizing HA–lipid conjugates. HA is an endogenous vitreal polysaccharide and a potential targeting moiety to cluster of differentiation 44 (CD44)-expressing cells. Light-activated drug release from 100 nm HA-coated liposomes was functional in buffer, plasma, and vitreous samples. The HA-coating improved stability in plasma compared to polyethylene glycol (PEG)-coated liposomes. Liposomal protein coronas on HA- and PEG-coated liposomes after dynamic exposure to undiluted human plasma and porcine vitreous samples were hydrophilic and negatively charged, thicker in plasma (~5 nm hard, ~10 nm soft coronas) than in vitreous (~2 nm hard, ~3 nm soft coronas) samples. Their compositions were dependent on liposome formulation and surface charge in plasma but not in vitreous samples. Compared to the PEG coating, the HA-coated liposomes bound more proteins in vitreous samples and enriched proteins related to collagen interactions, possibly explaining their slightly reduced vitreal mobility. The properties of the most abundant proteins did not correlate with liposome size or charge, but included proteins with surfactant and immune system functions in plasma and vitreous samples. The HA-coated light-activated liposomes are a functional and promising alternative for intravenous and ocular drug delivery. View Full-Text
Keywords: hyaluronic acid; liposome; drug release; light activation; stability; mobility; biocorona hyaluronic acid; liposome; drug release; light activation; stability; mobility; biocorona
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MDPI and ACS Style

Kari, O.K.; Tavakoli, S.; Parkkila, P.; Baan, S.; Savolainen, R.; Ruoslahti, T.; Johansson, N.G.; Ndika, J.; Alenius, H.; Viitala, T.; Urtti, A.; Lajunen, T. Light-Activated Liposomes Coated with Hyaluronic Acid as a Potential Drug Delivery System. Pharmaceutics 2020, 12, 763. https://doi.org/10.3390/pharmaceutics12080763

AMA Style

Kari OK, Tavakoli S, Parkkila P, Baan S, Savolainen R, Ruoslahti T, Johansson NG, Ndika J, Alenius H, Viitala T, Urtti A, Lajunen T. Light-Activated Liposomes Coated with Hyaluronic Acid as a Potential Drug Delivery System. Pharmaceutics. 2020; 12(8):763. https://doi.org/10.3390/pharmaceutics12080763

Chicago/Turabian Style

Kari, Otto K., Shirin Tavakoli, Petteri Parkkila, Simone Baan, Roosa Savolainen, Teemu Ruoslahti, Niklas G. Johansson, Joseph Ndika, Harri Alenius, Tapani Viitala, Arto Urtti, and Tatu Lajunen. 2020. "Light-Activated Liposomes Coated with Hyaluronic Acid as a Potential Drug Delivery System" Pharmaceutics 12, no. 8: 763. https://doi.org/10.3390/pharmaceutics12080763

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