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Open AccessArticle

Optimization of Drug Permeation from 8% Ciclopirox Cyclodextrin/Poloxamer-Soluble Polypseudorotaxane-Based Nail Lacquers

Department of Pharmacology, Pharmacy and Pharmaceutical Technology, University of Santiago de Compostela, Santiago de Compostela 15782, Spain
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Pharmaceutics 2020, 12(3), 231; https://doi.org/10.3390/pharmaceutics12030231
Received: 15 January 2020 / Revised: 29 February 2020 / Accepted: 3 March 2020 / Published: 5 March 2020
(This article belongs to the Special Issue Antifungal and Antiparasitic Drug Delivery Volume II)
Cyclodextrin/poloxamer-soluble polypseudorotaxane-based nail lacquers have demonstrated significant capacity for promoting the permeation of drugs into the nail plate. Furthermore, previous studies have shown that the use of hydroalcoholic blends as vehicles promotes drug permeation. The work described herein studies the effect of the type of alcohol used in the lacquer preparation, and the composition of the vehicle is optimized to obtain soluble doses of 8% and to promote the diffusion of ciclopirox base and olamine across the nail. Permeation studies on different types of alcohols show that optimum results are achieved with short-chain alcohols, and that results become less satisfactory the higher the number of alcohol carbons. In addition, solubility and penetration studies on the bovine hoof have enabled the composition of the lacquer to be optimized for both forms of ciclopirox. The results suggest that optimized lacquers have better ciclopirox diffusion and penetration properties than the commercial reference lacquer. Lastly, in vivo studies in which optimized ciclopirox olamine lacquer was applied for 45 days to the nails of healthy volunteers showed that it caused no negative effects or changes to the nail surface. These results demonstrate the significant potential of cyclodextrin/poloxamer-soluble polypseudorotaxane-based nail lacquers for the ungual administration of drugs. View Full-Text
Keywords: transungual drug delivery; nail; medicated nail lacquers; onychomycosis; polypseudorotaxanes; methyl-β-cyclodextrin; poloxamers; ciclopirox olamine; ciclopirox base transungual drug delivery; nail; medicated nail lacquers; onychomycosis; polypseudorotaxanes; methyl-β-cyclodextrin; poloxamers; ciclopirox olamine; ciclopirox base
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MDPI and ACS Style

Cutrín-Gómez, E.; Conde-Penedo, A.; Anguiano-Igea, S.; Gómez-Amoza, J.L.; Otero-Espinar, F.J. Optimization of Drug Permeation from 8% Ciclopirox Cyclodextrin/Poloxamer-Soluble Polypseudorotaxane-Based Nail Lacquers. Pharmaceutics 2020, 12, 231.

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