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Open AccessArticle

Encapsulation of a Ru(II) Polypyridyl Complex into Polylactide Nanoparticles for Antimicrobial Photodynamic Therapy

1
Institut de Recherche de Chimie Paris, CNRS, Chimie ParisTech, PSL University, 75005 Paris, France
2
Laboratory for Inorganic Chemical Biology, Institute of Chemistry for Life and Health Sciences, CNRS, Chimie ParisTech, PSL University, 75005 Paris, France
3
Laboratoire PEIRENE, Limoges University, EA 7500, 123 Avenue Albert Thomas, 87060 Limoges, France
*
Authors to whom correspondence should be addressed.
Pharmaceutics 2020, 12(10), 961; https://doi.org/10.3390/pharmaceutics12100961
Received: 10 August 2020 / Revised: 9 October 2020 / Accepted: 9 October 2020 / Published: 13 October 2020
Antimicrobial photodynamic therapy (aPDT) also known as photodynamic inactivation (PDI) is a promising strategy to eradicate pathogenic microorganisms such as Gram-positive and Gram-negative bacteria. This therapy relies on the use of a molecule called photosensitizer capable of generating, from molecular oxygen, reactive oxygen species including singlet oxygen under light irradiation to induce bacteria inactivation. Ru(II) polypyridyl complexes can be considered as potential photosensitizers for aPDT/PDI. However, to allow efficient treatment, they must be able to penetrate bacteria. This can be promoted by using nanoparticles. In this work, ruthenium-polylactide (RuPLA) nanoconjugates with different tacticities and molecular weights were prepared from a Ru(II) polypyridyl complex, RuOH. Narrowly-dispersed nanoparticles with high ruthenium loadings (up to 53%) and an intensity-average diameter < 300 nm were obtained by nanoprecipitation, as characterized by dynamic light scattering (DLS). Their phototoxicity effect was evaluated on four bacterial strains (Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli and Pseudomonas aeruginosa) and compared to the parent compound RuOH. RuOH and the nanoparticles were found to be non-active towards Gram-negative bacterial strains. However, depending on the tacticity and molecular weight of the RuPLA nanoconjugates, differences in photobactericidal activity on Gram-positive bacterial strains have been evidenced whereas RuOH remained non active. View Full-Text
Keywords: antimicrobial photodynamic therapy; nanoparticles; photodynamic inactivation; polylactide; ruthenium complexes antimicrobial photodynamic therapy; nanoparticles; photodynamic inactivation; polylactide; ruthenium complexes
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MDPI and ACS Style

Soliman, N.; Sol, V.; Ouk, T.-S.; Thomas, C.M.; Gasser, G. Encapsulation of a Ru(II) Polypyridyl Complex into Polylactide Nanoparticles for Antimicrobial Photodynamic Therapy. Pharmaceutics 2020, 12, 961.

AMA Style

Soliman N, Sol V, Ouk T-S, Thomas CM, Gasser G. Encapsulation of a Ru(II) Polypyridyl Complex into Polylactide Nanoparticles for Antimicrobial Photodynamic Therapy. Pharmaceutics. 2020; 12(10):961.

Chicago/Turabian Style

Soliman, Nancy; Sol, Vincent; Ouk, Tan-Sothea; Thomas, Christophe M.; Gasser, Gilles. 2020. "Encapsulation of a Ru(II) Polypyridyl Complex into Polylactide Nanoparticles for Antimicrobial Photodynamic Therapy" Pharmaceutics 12, no. 10: 961.

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