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Article

Nanoemulsion Stabilized by Safe Surfactin from Bacillus subtilis as a Multifunctional, Custom-Designed Smart Delivery System

1
Faculty of Chemistry, University of Wroclaw, Joliot-Curie 14, 50-383 Wroclaw, Poland
2
Department of Biotransformation, Faculty of Biotechnology, University of Wroclaw, Joliot-Curie 14a, 50-383 Wroclaw, Poland
3
Department of Lipids and Liposomes, Faculty of Biotechnology, University of Wroclaw, Joliot-Curie 14a, 50-383 Wroclaw, Poland
*
Authors to whom correspondence should be addressed.
Pharmaceutics 2020, 12(10), 953; https://doi.org/10.3390/pharmaceutics12100953
Received: 16 September 2020 / Revised: 2 October 2020 / Accepted: 7 October 2020 / Published: 10 October 2020
The developing field of bio-nanotechnology aims to advance colloidal research via the introduction of multifunctional nanoparticles to augment the dermal effectiveness of active substances. Self-emulsifying drug delivery systems (SEDDS)—isotropic mixtures of oils, surfactants, solvents and co-solvents or surfactants—are attracting interest in the cosmeceutical field. As part of this study, SEDDS systems containing vitamin C or vitamin E and curcumin were developed, whereby the bioavailability of the active compounds increased by enhancing their permeability to deeper layers of the skin. A composition consisting of 50% surfactin from Bacillus subtilis, 30% Transcutol and 20% oil phase was designed to encapsulate the active substances, i.e., vitamin C or vitamin E and curcumin, contained in the oil phase. The developed carriers were characterized by average particle sizes of 69–183 nm. The formulations with the vitamins were found to be physically and chemically stable for 6 months. Transdermal tests were carried out, showing that the carriers enable the transport of active substances deep into the skin, stopping at the dermis border. The formulations with vitamin C and vitamin E reduced the discoloration, the vascular lesions, and the depth of the wrinkles on the tested skin, which can be useful in cosmetics in the treatment of problem skin, including capillary and sensitive skin. View Full-Text
Keywords: surfactin; surfactant; Bacillus subtilis; delivery system; nanocarrier; skin; stability surfactin; surfactant; Bacillus subtilis; delivery system; nanocarrier; skin; stability
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MDPI and ACS Style

Lewińska, A.; Domżał-Kędzia, M.; Jaromin, A.; Łukaszewicz, M. Nanoemulsion Stabilized by Safe Surfactin from Bacillus subtilis as a Multifunctional, Custom-Designed Smart Delivery System. Pharmaceutics 2020, 12, 953. https://doi.org/10.3390/pharmaceutics12100953

AMA Style

Lewińska A, Domżał-Kędzia M, Jaromin A, Łukaszewicz M. Nanoemulsion Stabilized by Safe Surfactin from Bacillus subtilis as a Multifunctional, Custom-Designed Smart Delivery System. Pharmaceutics. 2020; 12(10):953. https://doi.org/10.3390/pharmaceutics12100953

Chicago/Turabian Style

Lewińska, Agnieszka; Domżał-Kędzia, Marta; Jaromin, Anna; Łukaszewicz, Marcin. 2020. "Nanoemulsion Stabilized by Safe Surfactin from Bacillus subtilis as a Multifunctional, Custom-Designed Smart Delivery System" Pharmaceutics 12, no. 10: 953. https://doi.org/10.3390/pharmaceutics12100953

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