Next Article in Journal
Therapeutic Interventions into Innate Immune Diseases by Means of Aptamers
Previous Article in Journal
Nanoemulsion Stabilized by Safe Surfactin from Bacillus subtilis as a Multifunctional, Custom-Designed Smart Delivery System
Article

Effective Dispensing Methods for Loading Drugs Only to the Tip of DNA Microneedles

1
Nano-Convergence Mechanical Systems Research Division, Korea Institute of Machinery and Materials, Daejeon 34103, Korea
2
Department of Fiber System Engineering, Dankook University, Yongin 448-701, Korea
3
Department of Science Education/Creative Convergent Manufacturing Engineering, Dankook University, Yongin 448-701, Korea
4
Department of Nano Mechatronics, University of Science and Technology (UST), Daejeon 34113, Korea
*
Authors to whom correspondence should be addressed.
Pharmaceutics 2020, 12(10), 954; https://doi.org/10.3390/pharmaceutics12100954
Received: 13 August 2020 / Revised: 3 October 2020 / Accepted: 7 October 2020 / Published: 10 October 2020
(This article belongs to the Special Issue Microneedle-Enhanced Dermal Delivery)
Here, we propose a novel and simple method to efficiently capture the diffusion of fluorescein isothiocyanate (FITC)-dextran from a biocompatible substance and load the drug only to the tip of DNA microneedles. A dispensing and suction method was chosen to fabricate the designed microneedles with efficient amounts of FITC as the drug model. Importantly, the vacuum process, which could influence the capturing of FITC diffusion from the tip, was evaluated during the manufacturing process. In addition, the simulations were consistent with the experimental results and showed apparent diffusion. Moreover, dextrans of different molecular weights labeled with FITC were chosen to fabricate the tip of microneedles for demonstrating their applicability. Finally, a micro-jetting system with a micro-nozzle (diameter: 80 μm) was developed to achieve the accurate and rapid loading of small amounts of FITC using the anti-diffusion and micro-jetting methods. Our method not only uses a simple and fast manufacturing process, but also fabricates the tips of microneedles more efficiently with FITC compared with the existing methods. We believe that the proposed method is essential for the clinical applications of the microneedle drug delivery platform. View Full-Text
Keywords: microneedles; dispensing method; anti-diffusion; FITC; micro-jetting microneedles; dispensing method; anti-diffusion; FITC; micro-jetting
Show Figures

Figure 1

MDPI and ACS Style

Bok, M.; Zhao, Z.-J.; Hwang, S.H.; Kang, H.-J.; Jeon, S.; Ko, J.; Jeong, J.; Song, Y.S.; Lim, E.; Jeong, J.-H. Effective Dispensing Methods for Loading Drugs Only to the Tip of DNA Microneedles. Pharmaceutics 2020, 12, 954. https://doi.org/10.3390/pharmaceutics12100954

AMA Style

Bok M, Zhao Z-J, Hwang SH, Kang H-J, Jeon S, Ko J, Jeong J, Song YS, Lim E, Jeong J-H. Effective Dispensing Methods for Loading Drugs Only to the Tip of DNA Microneedles. Pharmaceutics. 2020; 12(10):954. https://doi.org/10.3390/pharmaceutics12100954

Chicago/Turabian Style

Bok, Moonjeong, Zhi-Jun Zhao, Soon H. Hwang, Hyeok-Joong Kang, Sohee Jeon, Jiwoo Ko, Jiwon Jeong, Young S. Song, Eunju Lim, and Jun-Ho Jeong. 2020. "Effective Dispensing Methods for Loading Drugs Only to the Tip of DNA Microneedles" Pharmaceutics 12, no. 10: 954. https://doi.org/10.3390/pharmaceutics12100954

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop