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Norovirus Capsid Protein-Derived Nanoparticles and Polymers as Versatile Platforms for Antigen Presentation and Vaccine Development

by 1,2,* and 1,2,*
1
Division of Infectious Diseases, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA
2
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
*
Authors to whom correspondence should be addressed.
Pharmaceutics 2019, 11(9), 472; https://doi.org/10.3390/pharmaceutics11090472
Received: 31 July 2019 / Revised: 27 August 2019 / Accepted: 9 September 2019 / Published: 12 September 2019
(This article belongs to the Special Issue Nanoparticles to Improve the Efficacy of Vaccines)
Major viral structural proteins interact homotypically and/or heterotypically, self-assembling into polyvalent viral capsids that usually elicit strong host immune responses. By taking advantage of such intrinsic features of norovirus capsids, two subviral nanoparticles, 60-valent S60 and 24-valent P24 nanoparticles, as well as various polymers, have been generated through bioengineering norovirus capsid shell (S) and protruding (P) domains, respectively. These nanoparticles and polymers are easily produced, highly stable, and extremely immunogenic, making them ideal vaccine candidates against noroviruses. In addition, they serve as multifunctional platforms to display foreign antigens, self-assembling into chimeric nanoparticles or polymers as vaccines against different pathogens and illnesses. Several chimeric S60 and P24 nanoparticles, as well as P domain-derived polymers, carrying different foreign antigens, have been created and demonstrated to be promising vaccine candidates against corresponding pathogens in preclinical animal studies, warranting their further development into useful vaccines. View Full-Text
Keywords: nanoparticle; vaccine platform; P particle; S particle; protein polymer; subviral particle; subunit vaccine; norovirus; rotavirus; hepatitis E virus; astrovirus nanoparticle; vaccine platform; P particle; S particle; protein polymer; subviral particle; subunit vaccine; norovirus; rotavirus; hepatitis E virus; astrovirus
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MDPI and ACS Style

Tan, M.; Jiang, X. Norovirus Capsid Protein-Derived Nanoparticles and Polymers as Versatile Platforms for Antigen Presentation and Vaccine Development. Pharmaceutics 2019, 11, 472. https://doi.org/10.3390/pharmaceutics11090472

AMA Style

Tan M, Jiang X. Norovirus Capsid Protein-Derived Nanoparticles and Polymers as Versatile Platforms for Antigen Presentation and Vaccine Development. Pharmaceutics. 2019; 11(9):472. https://doi.org/10.3390/pharmaceutics11090472

Chicago/Turabian Style

Tan, Ming; Jiang, Xi. 2019. "Norovirus Capsid Protein-Derived Nanoparticles and Polymers as Versatile Platforms for Antigen Presentation and Vaccine Development" Pharmaceutics 11, no. 9: 472. https://doi.org/10.3390/pharmaceutics11090472

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