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Open AccessArticle

Physico-Chemical and Biological Evaluation of PLCL/SF Nanofibers Loaded with Oregano Essential Oil

1
College of Chemistry, Chemical Engineering & Biotechnology, Donghua University, Shanghai 201620, China
2
Institute of Biotechnology and Genetic Engineering, University of Sindh, Jamshoro 76080, Pakistan
3
Chemistry Department, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia
*
Author to whom correspondence should be addressed.
Pharmaceutics 2019, 11(8), 386; https://doi.org/10.3390/pharmaceutics11080386
Received: 29 June 2019 / Revised: 24 July 2019 / Accepted: 26 July 2019 / Published: 2 August 2019
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Abstract

Essential oils are complex volatile compounds, extracted from specific plant species, with promising therapeutic potentials. However, their volatile nature presents a major hindrance in using them as therapeutic agents. In the current study, we successfully encapsulated oregano essential oil (OEO) into Poly (l-lactic acid-co-e-caprolactone) /Silk Fibroin (PLCL/SF) polymers through electrospinning. The nanofibrous membrane (NF) was fabricated and characterized for various physico-chemical and biological attributions. Homogenous and bead free morphology was confirmed by scanning electron microscopy (SEM). Attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) confirmed the successful loading of OEO and its physical interaction with the blend of PLCL/SF. Moreover, thermogravimetric analysis (TGA) also confirmed the successful loading and thermostability of the OEO. Although a significant change was noted in tensile strength due to the loading of OEO, the mechanical behaviour still falls into the acceptable ranges required for skin tissue engineering. Similarly, fabricated material was evaluated for its biological significance. Liquid chromatography-mass spectrometry (LC-MS) was employed to determine the release behaviour of OEO from electrospun membranes. LC-MS data, noted for 48 h, confirmed the biphasic release of OEO. Furthermore, NF membranes have shown strong antioxidant and anti-tumor activities. This material is promising and can be implanted to avoid the recurrence of the tumor after its surgical removal. View Full-Text
Keywords: oregano essential oil; electrospun nanofibers PLCL; SF; drug release; mechanical properties; antioxidant activity; anti-tumor activity oregano essential oil; electrospun nanofibers PLCL; SF; drug release; mechanical properties; antioxidant activity; anti-tumor activity
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Khan, A.R.; Nadeem, M.; Bhutto, M.A.; Yu, F.; Xie, X.; El-Hamshary, H.; El-Faham, A.; Ibrahim, U.A.; Mo, X. Physico-Chemical and Biological Evaluation of PLCL/SF Nanofibers Loaded with Oregano Essential Oil. Pharmaceutics 2019, 11, 386.

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