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Open AccessArticle

Potential Albumin-Based Antioxidant Nanoformulations for Ocular Protection against Oxidative Stress

1
College of Pharmacy and Inje Institute of Pharmaceutical Sciences and Research, Inje University, 197 Injero, Gimhae, Gyeongnam 50834, Korea
2
College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, 501 Jinju Daero, Jinju, Gyeongnam 52828, Korea
3
Department of Ophthalmology, College of Medicine, Inje University, 75 Bokjiro, Busanjin-gu, Busan 47392, Korea
4
T2B infrastructure center for ocular diseases, Inje University Busan Paik Hospital, 75 Bokjiro, Busanjin-gu, Busan 47392, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally.
Pharmaceutics 2019, 11(7), 297; https://doi.org/10.3390/pharmaceutics11070297
Received: 31 May 2019 / Revised: 22 June 2019 / Accepted: 24 June 2019 / Published: 26 June 2019
(This article belongs to the Special Issue Advanced Formulation Approaches for Targeted Drug Delivery)
Amongst various drug administration methods, ophthalmic drug delivery has been a useful way for the treatment of eye-related diseases. However, therapeutic efficacy of ocular therapy for anterior or posterior eye segments through topical administration is considerably challenged by the number of anatomical and physiological barriers in the eyes affecting ocular bioavailability. In this respect, advanced biocompatible nanoformulations make it possible to improve drug delivery to the target sites and enhance ocular bioavailability of ophthalmic medicines. Various ocular diseases have been reported to be related to oxidative stresses in tissues, and polyphenolic compounds have been known for their antioxidant activities in various tissues, including the eyes. Despite drug efficacy, poor water solubility and intrinsic color of the compounds limit the drug’s inclusion into the development of ocular medicine. In the present study, we investigated the antioxidant protectant efficacy of rosmarinic or ursolic acid in the retinal epithelial cells, as compared to those of curcumin, by forming nanospheres with bovine serum albumin. Our results demonstrate that antioxidant-containing nanoformulations provide a significantly higher drug solubility and decreased ROS (reactive oxygen species) production in the retinal epithelial cells. Finally, we also found that albumin-based nanoformulations could improve bioavailability and increase antioxidant activity of rosmarinic or ursolic acid in the retina to be applied as efficient ocular protectant. View Full-Text
Keywords: antioxidant; bovine serum albumin; ophthalmic formulation; drug transport; cornea; retinal pigmented epithelium antioxidant; bovine serum albumin; ophthalmic formulation; drug transport; cornea; retinal pigmented epithelium
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MDPI and ACS Style

Kim, D.; Maharjan, P.; Jin, M.; Park, T.; Maharjan, A.; Amatya, R.; Yang, J.; Min, K.A.; Shin, M.C. Potential Albumin-Based Antioxidant Nanoformulations for Ocular Protection against Oxidative Stress. Pharmaceutics 2019, 11, 297.

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