Next Article in Journal
In Vitro Anticancer Activity of Extracellular Vesicles (EVs) Secreted by Gingival Mesenchymal Stromal Cells Primed with Paclitaxel
Next Article in Special Issue
Enhanced Transepithelial Permeation of Gallic Acid and (−)-Epigallocatechin Gallate across Human Intestinal Caco-2 Cells Using Electrospun Xanthan Nanofibers
Previous Article in Journal
Chlorambucil Conjugated Ugi Dendrimers with PAMAM-NH2 Core and Evaluation of Their Anticancer Activity
Previous Article in Special Issue
Development of A New Delivery System Based on Drug-Loadable Electrospun Nanofibers for Psoriasis Treatment
Open AccessArticle

Gold Nanocage-Incorporated Poly(ε-Caprolactone) (PCL) Fibers for Chemophotothermal Synergistic Cancer Therapy

1
Department of Polymer Science and Engineering, Kyungpook National University, Daegu 41566, Korea
2
Dongnam Regional Division, Korea Institute of Industrial Technology, Busan 46938, Korea
3
Department of Materials Science and Engineering, Kumoh National Institute of Technology, Gumi, Gyeongbuk 39177, Korea
*
Authors to whom correspondence should be addressed.
Pharmaceutics 2019, 11(2), 60; https://doi.org/10.3390/pharmaceutics11020060
Received: 29 November 2018 / Revised: 27 December 2018 / Accepted: 28 December 2018 / Published: 1 February 2019
(This article belongs to the Special Issue Electrospun and Electrosprayed Formulations for Drug Delivery)
This paper introduces a new fibrous system for synergistic cancer therapy, which consists of gold nanocage (AuNC)-loaded poly(ε-caprolactone) (PCL) fibers with encapsulation of a chemotherapeutic anticancer drug in their core and loading of a phase-changeable fatty acid in their sheath. Under on–off switching of near-infrared (NIR) light irradiation, the excellent photothermal ability and photostability of AuNCs allows repeated, significant heating of the fibers to a temperature available to hyperthermia. Simultaneously, the NIR light-induced heat generation enables the melting out of the loaded fatty acid, leading to a rapid release of the drug molecules from the fibers. The combination of this NIR light-triggered drug release with the repeated hyperthermia treatment exhibits excellent anticancer efficacy. View Full-Text
Keywords: PCL; electrospinning; combination therapy; photothermal therapy; NIR-triggered drug release PCL; electrospinning; combination therapy; photothermal therapy; NIR-triggered drug release
Show Figures

Graphical abstract

MDPI and ACS Style

Park, J.H.; Seo, H.; Kim, D.I.; Choi, J.H.; Son, J.H.; Kim, J.; Moon, G.D.; Hyun, D.C. Gold Nanocage-Incorporated Poly(ε-Caprolactone) (PCL) Fibers for Chemophotothermal Synergistic Cancer Therapy. Pharmaceutics 2019, 11, 60. https://doi.org/10.3390/pharmaceutics11020060

AMA Style

Park JH, Seo H, Kim DI, Choi JH, Son JH, Kim J, Moon GD, Hyun DC. Gold Nanocage-Incorporated Poly(ε-Caprolactone) (PCL) Fibers for Chemophotothermal Synergistic Cancer Therapy. Pharmaceutics. 2019; 11(2):60. https://doi.org/10.3390/pharmaceutics11020060

Chicago/Turabian Style

Park, Ju H.; Seo, Hojun; Kim, Da I.; Choi, Ji H.; Son, Jin H.; Kim, Jongbok; Moon, Geon D.; Hyun, Dong C. 2019. "Gold Nanocage-Incorporated Poly(ε-Caprolactone) (PCL) Fibers for Chemophotothermal Synergistic Cancer Therapy" Pharmaceutics 11, no. 2: 60. https://doi.org/10.3390/pharmaceutics11020060

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop