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Pharmaceutics 2018, 10(2), 67; https://doi.org/10.3390/pharmaceutics10020067

Twin Screw Granulation: An Investigation of the Effect of Barrel Fill Level

Department of Chemical and Biological Engineering, University of Sheffield, Mappin Street, Sheffield S1 3JD, UK
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Received: 23 April 2018 / Revised: 17 May 2018 / Accepted: 26 May 2018 / Published: 1 June 2018
(This article belongs to the Special Issue Pharmaceutical Applications of Hot-melt Extrusion)
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Abstract

This paper focuses on investigating the influence of varying barrel fill levels on the mean residence time, granule properties (median size, size distribution, and shape), and tensile strength of tablets. Specific feed load (SFL) (powder feed rate divided by screw speed) and powder feed number (PFN) (i.e., powder mass flow rate divided by the product of screw speed, screw diameter, and the material density in the denominator) were considered as surrogates for the barrel fill level. Two type of powders (lactose and microcrystalline cellulose (MCC)) were granulated separately at varying fill levels at different liquid-to-solid ratios (L/S). It was observed that by controlling the barrel fill level, the granule size, shape, and tablet tensile strength can be maintained at specific L/S. It was also noticed that the mean residence time decreased with increasing fill levels in the case of both lactose and MCC powder. However, it was only found to be related to the change in granule size in case of granulating microcrystalline cellulose at varying fill levels. At very high fill levels, granule size decreased, owing to a limited interaction between MCC powder and liquid at high throughput force and short residence time. View Full-Text
Keywords: twin screw granulation; continuous; barrel fill; lactose; microcrystalline cellulose; tableting twin screw granulation; continuous; barrel fill; lactose; microcrystalline cellulose; tableting
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Lute, S.V.; Dhenge, R.M.; Salman, A.D. Twin Screw Granulation: An Investigation of the Effect of Barrel Fill Level. Pharmaceutics 2018, 10, 67.

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