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Pharmaceutics 2018, 10(2), 68;

Twin Screw Granulation: Effects of Properties of Primary Powders

Department of Chemical and Biological Engineering, University of Sheffield, Mappin Street, Sheffield S1 3JD, UK
Author to whom correspondence should be addressed.
Received: 23 April 2018 / Revised: 28 May 2018 / Accepted: 30 May 2018 / Published: 2 June 2018
(This article belongs to the Special Issue Pharmaceutical Applications of Hot-melt Extrusion)
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Lactose and mannitol are some of the most commonly used powders in the pharmaceutical industry. The limited research published so far highlights the effects of process and formulation parameters on the properties of the granules and the tablets produced using these two types of powders separately. However, the comparison of the performance of these two types of powders during twin screw wet granulation has received no attention. The present research is focused on understanding the granulation mechanism of different grades of two pharmaceutical powders with varying properties (i.e., primary particle size, structure, and compressibility). Three grades each of lactose and mannitol were granulated at varying liquid to solid ratios (L/S) and screw speed. It was noticed that primary powder morphology plays an important role in determining the granule size and structure, and tablet tensile strength. It was indicated that the processed powders such as spray-dried and granulated lactose and mannitol can be used in formulation for wet granulation where flowability of active pharmaceutical ingredient (API) is poor. View Full-Text
Keywords: twin screw wet granulation; continuous; excipient; granule; lactose; mannitol; tableting twin screw wet granulation; continuous; excipient; granule; lactose; mannitol; tableting

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Lute, S.V.; Dhenge, R.M.; Salman, A.D. Twin Screw Granulation: Effects of Properties of Primary Powders. Pharmaceutics 2018, 10, 68.

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