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Viruses 2017, 9(10), 291;

Innate Immune Evasion Mediated by Flaviviridae Non-Structural Proteins

1,2,3,*,†, 1,†, 1,2,3 and 1,2,3,*
Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
Research Center of Avian Disease, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu 611130, China
Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu 611130, China
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Received: 20 September 2017 / Revised: 3 October 2017 / Accepted: 5 October 2017 / Published: 7 October 2017
(This article belongs to the Collection Advances in Ebolavirus, Marburgvirus, and Cuevavirus Research)
PDF [1247 KB, uploaded 12 October 2017]


Flaviviridae-caused diseases are a critical, emerging public health problem worldwide. Flaviviridae infections usually cause severe, acute or chronic diseases, such as liver damage and liver cancer resulting from a hepatitis C virus (HCV) infection and high fever and shock caused by yellow fever. Many researchers worldwide are investigating the mechanisms by which Flaviviridae cause severe diseases. Flaviviridae can interfere with the host’s innate immunity to achieve their purpose of proliferation. For instance, dengue virus (DENV) NS2A, NS2B3, NS4A, NS4B and NS5; HCV NS2, NS3, NS3/4A, NS4B and NS5A; and West Nile virus (WNV) NS1 and NS4B proteins are involved in immune evasion. This review discusses the interplay between viral non-structural Flaviviridae proteins and relevant host proteins, which leads to the suppression of the host’s innate antiviral immunity. View Full-Text
Keywords: flavivirus; HCV; non-structural protein; immune evasion; emergence flavivirus; HCV; non-structural protein; immune evasion; emergence

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Chen, S.; Wu, Z.; Wang, M.; Cheng, A. Innate Immune Evasion Mediated by Flaviviridae Non-Structural Proteins. Viruses 2017, 9, 291.

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