The Bcl-2 Family in Host-Virus Interactions
1
Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia
2
Department of Chemistry and Physics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia
*
Authors to whom correspondence should be addressed.
Viruses 2017, 9(10), 290; https://doi.org/10.3390/v9100290
Received: 22 September 2017 / Revised: 1 October 2017 / Accepted: 3 October 2017 / Published: 6 October 2017
(This article belongs to the Special Issue Viral Infection and Apoptosis)
Members of the B cell lymphoma-2 (Bcl-2) family are pivotal arbiters of mitochondrially mediated apoptosis, a process of fundamental importance during tissue development, homeostasis, and disease. At the structural and mechanistic level, the mammalian members of the Bcl-2 family are increasingly well understood, with their interplay ultimately deciding the fate of a cell. Dysregulation of Bcl-2-mediated apoptosis underlies a plethora of diseases, and numerous viruses have acquired homologs of Bcl-2 to subvert host cell apoptosis and autophagy to prevent premature death of an infected cell. Here we review the structural biology, interactions, and mechanisms of action of virus-encoded Bcl-2 proteins, and how they impact on host-virus interactions to ultimately enable successful establishment and propagation of viral infections.
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Keywords:
Bcl-2; apoptosis; autophagy; structural biology; poxvirus; herpesvirus; asfarvirus; iridovirus; adenovirus; host-pathogen interactions
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Kvansakul, M.; Caria, S.; Hinds, M.G. The Bcl-2 Family in Host-Virus Interactions. Viruses 2017, 9, 290. https://doi.org/10.3390/v9100290
AMA Style
Kvansakul M, Caria S, Hinds MG. The Bcl-2 Family in Host-Virus Interactions. Viruses. 2017; 9(10):290. https://doi.org/10.3390/v9100290
Chicago/Turabian StyleKvansakul, Marc; Caria, Sofia; Hinds, Mark G. 2017. "The Bcl-2 Family in Host-Virus Interactions" Viruses 9, no. 10: 290. https://doi.org/10.3390/v9100290
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