The Bcl-2 Family in Host-Virus Interactions
AbstractMembers of the B cell lymphoma-2 (Bcl-2) family are pivotal arbiters of mitochondrially mediated apoptosis, a process of fundamental importance during tissue development, homeostasis, and disease. At the structural and mechanistic level, the mammalian members of the Bcl-2 family are increasingly well understood, with their interplay ultimately deciding the fate of a cell. Dysregulation of Bcl-2-mediated apoptosis underlies a plethora of diseases, and numerous viruses have acquired homologs of Bcl-2 to subvert host cell apoptosis and autophagy to prevent premature death of an infected cell. Here we review the structural biology, interactions, and mechanisms of action of virus-encoded Bcl-2 proteins, and how they impact on host-virus interactions to ultimately enable successful establishment and propagation of viral infections. View Full-Text
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Kvansakul, M.; Caria, S.; Hinds, M.G. The Bcl-2 Family in Host-Virus Interactions. Viruses 2017, 9, 290.
Kvansakul M, Caria S, Hinds MG. The Bcl-2 Family in Host-Virus Interactions. Viruses. 2017; 9(10):290.Chicago/Turabian Style
Kvansakul, Marc; Caria, Sofia; Hinds, Mark G. 2017. "The Bcl-2 Family in Host-Virus Interactions." Viruses 9, no. 10: 290.
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