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Viruses 2016, 8(2), 50;

Structural Proteomics of Herpesviruses

Laboratory of Proteomic and Microbiology, Research Institute of Biosciences, University of MONS, 4000 Mons, Belgium
Immunology-Vaccinology, Department of Infectious and Parasitic Diseases, Fundamental and Applied Research for Animals and Health, Faculty of Veterinary Medicine, University of Liege, 4000 Liege, Belgium
Author to whom correspondence should be addressed.
Received: 30 October 2015 / Revised: 15 January 2016 / Accepted: 4 February 2016 / Published: 12 February 2016
(This article belongs to the Section Animal Viruses)
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Herpesviruses are highly prevalent viruses associated with numerous pathologies both in animal and human populations. Until now, most of the strategies used to prevent or to cure these infections have been unsuccessful because these viruses have developed numerous immune evasion mechanisms. Therefore, a better understanding of their complex lifecycle is needed. In particular, while the genome of numerous herpesviruses has been sequenced, the exact composition of virions remains unknown for most of them. Mass spectrometry has recently emerged as a central method and has permitted fundamental discoveries in virology. Here, we review mass spectrometry-based approaches that have recently allowed a better understanding of the composition of the herpesvirus virion. In particular, we describe strategies commonly used for proper sample preparation and fractionation to allow protein localization inside the particle but also to avoid contamination by nonstructural proteins. A collection of other important data regarding post-translational modifications or the relative abundance of structural proteins is also described. This review also discusses the poorly studied importance of host proteins in herpesvirus structural proteins and the necessity to develop a quantitative workflow to better understand the dynamics of the structural proteome. In the future, we hope that this collaborative effort will assist in the development of new strategies to fight these infections. View Full-Text
Keywords: herpesvirus; structural proteins; proteomic; host proteins herpesvirus; structural proteins; proteomic; host proteins

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Leroy, B.; Gillet, L.; Vanderplasschen, A.; Wattiez, R. Structural Proteomics of Herpesviruses. Viruses 2016, 8, 50.

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