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Viruses 2015, 7(1), 199-218;

HIV-1 Replication and the Cellular Eukaryotic Translation Apparatus

Architecture et Réactivité de l'ARN, CNRS, Université de Strasbourg, Institut de Biologie Moléculaire et Cellulaire, 15 rue René Descartes, 67084 Strasbourg cedex, France
Present Address: Centre for Genomic Regulation, Dr. Aiguader, 88, PRBB Building, 08003 Barcelona, Spain
Author to whom correspondence should be addressed.
Academic Editor: David Boehr
Received: 4 November 2014 / Accepted: 12 January 2015 / Published: 19 January 2015
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Eukaryotic translation is a complex process composed of three main steps: initiation, elongation, and termination. During infections by RNA- and DNA-viruses, the eukaryotic translation machinery is used to assure optimal viral protein synthesis. Human immunodeficiency virus type I (HIV-1) uses several non-canonical pathways to translate its own proteins, such as leaky scanning, frameshifting, shunt, and cap-independent mechanisms. Moreover, HIV-1 modulates the host translation machinery by targeting key translation factors and overcomes different cellular obstacles that affect protein translation. In this review, we describe how HIV-1 proteins target several components of the eukaryotic translation machinery, which consequently improves viral translation and replication. View Full-Text
Keywords: HIV-1; translation; auxiliary proteins; IRES; leaky-scanning; frameshift; ribosome shunting HIV-1; translation; auxiliary proteins; IRES; leaky-scanning; frameshift; ribosome shunting

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Guerrero, S.; Batisse, J.; Libre, C.; Bernacchi, S.; Marquet, R.; Paillart, J.-C. HIV-1 Replication and the Cellular Eukaryotic Translation Apparatus. Viruses 2015, 7, 199-218.

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