Screening for Congenital Cytomegalovirus Infection in Newborns

Zhang, Junfeng; Cao, Jiajia; Ye, Qing

doi:10.3390/v18010063

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Screening for Congenital Cytomegalovirus Infection in Newborns

by

Junfeng Zhang

,

Jiajia Cao

and

Qing Ye

^*

Department of Clinical Laboratory, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children’s Regional Medical Center, Hangzhou 310052, China

^*

Author to whom correspondence should be addressed.

Viruses 2026, 18(1), 63; https://doi.org/10.3390/v18010063

Submission received: 26 September 2025 / Revised: 23 December 2025 / Accepted: 29 December 2025 / Published: 31 December 2025

(This article belongs to the Section Human Virology and Viral Diseases)

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Abstract

Congenital cytomegalovirus infection is an underrecognized congenital infection. Globally, it impacts approximately 1 of every 200 live births. Although infected infants can have an increased risk of long-term sequelae, such as neurodevelopmental impairments and sensorineural hearing loss, most of the infected infants do not show visible signs at birth. As congenital cytomegalovirus infection often goes undetected and screening programs are not widely accepted, awareness of congenital cytomegalovirus in neonates is lacking. The aim of this study is to offer the current status of the epidemiology, clinical manifestations, and laboratory testing for the diagnosis of congenital cytomegalovirus infection and newborn screening approaches.

Keywords: cytomegalovirus; congenital infection; newborns; CMV

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MDPI and ACS Style

Zhang, J.; Cao, J.; Ye, Q. Screening for Congenital Cytomegalovirus Infection in Newborns. Viruses 2026, 18, 63. https://doi.org/10.3390/v18010063

AMA Style

Zhang J, Cao J, Ye Q. Screening for Congenital Cytomegalovirus Infection in Newborns. Viruses. 2026; 18(1):63. https://doi.org/10.3390/v18010063

Chicago/Turabian Style

Zhang, Junfeng, Jiajia Cao, and Qing Ye. 2026. "Screening for Congenital Cytomegalovirus Infection in Newborns" Viruses 18, no. 1: 63. https://doi.org/10.3390/v18010063

APA Style

Zhang, J., Cao, J., & Ye, Q. (2026). Screening for Congenital Cytomegalovirus Infection in Newborns. Viruses, 18(1), 63. https://doi.org/10.3390/v18010063

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Screening for Congenital Cytomegalovirus Infection in Newborns

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