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A Memory of Professor Robert B. Sim, D. Phil
Article

Acute Late-Stage Myocarditis in the Crab-Eating Macaque Model of Hemorrhagic Smallpox

1
Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, MD 21702, USA
2
Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA
3
Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA
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Advanced Cardiovascular Imaging Group, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Shan-Lu Liu
Viruses 2021, 13(8), 1571; https://doi.org/10.3390/v13081571
Received: 11 July 2021 / Revised: 30 July 2021 / Accepted: 1 August 2021 / Published: 9 August 2021
(This article belongs to the Section Animal Viruses)
Hemorrhagic smallpox, caused by variola virus (VARV), was a rare but nearly 100% lethal human disease manifestation. Hemorrhagic smallpox is frequently characterized by secondary bacterial infection, coagulopathy, and myocardial and subendocardial hemorrhages. Previous experiments have demonstrated that intravenous (IV) cowpox virus (CPXV) exposure of macaques mimics human hemorrhagic smallpox. The goal of this experiment was to further understand the onset, nature, and severity of cardiac pathology and how it may contribute to disease. The findings support an acute late-stage myocarditis with lymphohistiocytic infiltrates in the CPXV model of hemorrhagic smallpox. View Full-Text
Keywords: cowpox; CPXV; smallpox; variola; VARV; myocarditis; cardiac MRI; biodefense cowpox; CPXV; smallpox; variola; VARV; myocarditis; cardiac MRI; biodefense
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MDPI and ACS Style

Johnson, R.F.; Keith, L.A.; Cooper, T.K.; Yellayi, S.; Josleyn, N.M.; Janosko, K.B.; Pettitt, J.D.; Thomasson, D.; Hagen, K.R.; Gross, R.; Bernbaum, J.G.; Douglas, D.; Solomon, J.; Martinez, M.; Cooper, K.; St. Claire, M.; Ragland, D.R.; Jahrling, P.B.; Kuhn, J.H.; Arai, A.E. Acute Late-Stage Myocarditis in the Crab-Eating Macaque Model of Hemorrhagic Smallpox. Viruses 2021, 13, 1571. https://doi.org/10.3390/v13081571

AMA Style

Johnson RF, Keith LA, Cooper TK, Yellayi S, Josleyn NM, Janosko KB, Pettitt JD, Thomasson D, Hagen KR, Gross R, Bernbaum JG, Douglas D, Solomon J, Martinez M, Cooper K, St. Claire M, Ragland DR, Jahrling PB, Kuhn JH, Arai AE. Acute Late-Stage Myocarditis in the Crab-Eating Macaque Model of Hemorrhagic Smallpox. Viruses. 2021; 13(8):1571. https://doi.org/10.3390/v13081571

Chicago/Turabian Style

Johnson, Reed F., Lauren A. Keith, Timothy K. Cooper, Srikanth Yellayi, Nicole M. Josleyn, Krisztina B. Janosko, James D. Pettitt, David Thomasson, Katie R. Hagen, Robin Gross, John G. Bernbaum, Debbie Douglas, Jeffrey Solomon, Mark Martinez, Kurt Cooper, Marisa St. Claire, Danny R. Ragland, Peter B. Jahrling, Jens H. Kuhn, and Andrew E. Arai 2021. "Acute Late-Stage Myocarditis in the Crab-Eating Macaque Model of Hemorrhagic Smallpox" Viruses 13, no. 8: 1571. https://doi.org/10.3390/v13081571

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