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Article

Rise and Fall of SARS-CoV-2 Lineage A.27 in Germany

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Epidemiology of Highly Pathogenic Microorganisms, Robert Koch Institute, 13353 Berlin, Germany
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Influenza and other Respiratory Viruses, Robert Koch Institute, 13353 Berlin, Germany
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Methodology and Research Infrastructure, Bioinformatics, Robert Koch Institute, 13353 Berlin, Germany
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Methodology and Research Infrastructure, Information and Research Data Management, Robert Koch Institute, 13353 Berlin, Germany
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Methodology and Research Infrastructure, Genome Sequencing and Genomic Epidemiology, Robert Koch Institute, 13353 Berlin, Germany
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Systems Medicine of Infectious Disease, Robert Koch Institute, 13353 Berlin, Germany
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Infectious Disease Epidemiology, Robert Koch Institute, 13353 Berlin, Germany
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Authors to whom correspondence should be addressed.
Academic Editors: Manja Marz, Franziska Hufsky, Alba Pérez-Cataluña, Walter Randazzo, Gloria Sanchez and Fernando González-Candelas
Viruses 2021, 13(8), 1491; https://doi.org/10.3390/v13081491
Received: 8 July 2021 / Revised: 23 July 2021 / Accepted: 24 July 2021 / Published: 29 July 2021
(This article belongs to the Special Issue Virus Bioinformatics 2022)
Here, we report on the increasing frequency of the SARS-CoV-2 lineage A.27 in Germany during the first months of 2021. Genomic surveillance identified 710 A.27 genomes in Germany as of 2 May 2021, with a vast majority identified in laboratories from a single German state (Baden-Wuerttemberg, n = 572; 80.5%). Baden-Wuerttemberg is located near the border with France, from where most A.27 sequences were entered into public databases until May 2021. The first appearance of this lineage based on sequencing in a laboratory in Baden-Wuerttemberg can be dated to early January ’21. From then on, the relative abundance of A.27 increased until the end of February but has since declined—meanwhile, the abundance of B.1.1.7 increased in the region. The A.27 lineage shows a mutational pattern typical of VOIs/VOCs, including an accumulation of amino acid substitutions in the Spike glycoprotein. Among those, L18F, L452R and N501Y are located in the epitope regions of the N-terminal- (NTD) or receptor binding domain (RBD) and have been suggested to result in immune escape and higher transmissibility. In addition, A.27 does not show the D614G mutation typical for all VOIs/VOCs from the B lineage. Overall, A.27 should continue to be monitored nationally and internationally, even though the observed trend in Germany was initially displaced by B.1.1.7 (Alpha), while now B.1.617.2 (Delta) is on the rise. View Full-Text
Keywords: public health surveillance; SARS-CoV-2 variants; viral genomes; molecular sequence data public health surveillance; SARS-CoV-2 variants; viral genomes; molecular sequence data
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MDPI and ACS Style

Calvignac-Spencer, S.; Budt, M.; Huska, M.; Richard, H.; Leipold, L.; Grabenhenrich, L.; Semmler, T.; von Kleist, M.; Kröger, S.; Wolff, T.; Hölzer, M. Rise and Fall of SARS-CoV-2 Lineage A.27 in Germany. Viruses 2021, 13, 1491. https://doi.org/10.3390/v13081491

AMA Style

Calvignac-Spencer S, Budt M, Huska M, Richard H, Leipold L, Grabenhenrich L, Semmler T, von Kleist M, Kröger S, Wolff T, Hölzer M. Rise and Fall of SARS-CoV-2 Lineage A.27 in Germany. Viruses. 2021; 13(8):1491. https://doi.org/10.3390/v13081491

Chicago/Turabian Style

Calvignac-Spencer, Sébastien, Matthias Budt, Matthew Huska, Hugues Richard, Luca Leipold, Linus Grabenhenrich, Torsten Semmler, Max von Kleist, Stefan Kröger, Thorsten Wolff, and Martin Hölzer. 2021. "Rise and Fall of SARS-CoV-2 Lineage A.27 in Germany" Viruses 13, no. 8: 1491. https://doi.org/10.3390/v13081491

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