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Commentary

Are We Ready for NGS HIV Drug Resistance Testing? The Second “Winnipeg Consensus” Symposium

1
National HIV and Retrovirology Laboratories at JC Wilt Infectious Diseases Research Centre, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada
2
Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB R3E 0J9, Canada
3
IrsiCaixa AIDS Research Institute, Hospital Germans Trias i Pujol, s/n, 08916 Badalona, Catalonia, Spain
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Infectious Diseases Department, Hospital Germans Trias i Pujol, 08916 Badalona, Catalonia, Spain
5
Division of AIDS, Department of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9, Canada
6
British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC V6Z 1Y6, Canada
7
Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9, Canada
8
Centre for Research in Infectious Diseases, National Institute of Respiratory Diseases, Mexico City 14080, Mexico
9
Chair in AIDS and Related Illnesses, Centre for Health and Social Care Research (CESS), Faculty of Medicine, University of Vic–Central University of Catalonia (UVic–UCC), Can Baumann, Ctra. de Roda, 70, 08500 Vic, Spain
10
Data First Consulting Inc., Sebastopol, CA 95472, USA
11
Division of Infectious Diseases, Brown University Alpert Medical School, Providence, RI 02906, USA
*
Author to whom correspondence should be addressed.
Viruses 2020, 12(6), 586; https://doi.org/10.3390/v12060586
Received: 20 April 2020 / Revised: 13 May 2020 / Accepted: 25 May 2020 / Published: 27 May 2020
(This article belongs to the Special Issue Next Generation Sequencing for HIV Drug Resistance Testing)
HIV drug resistance is a major global challenge to successful and sustainable antiretroviral therapy. Next-generation sequencing (NGS)-based HIV drug resistance (HIVDR) assays enable more sensitive and quantitative detection of drug-resistance-associated mutations (DRMs) and outperform Sanger sequencing approaches in detecting lower abundance resistance mutations. While NGS is likely to become the new standard for routine HIVDR testing, many technical and knowledge gaps remain to be resolved before its generalized adoption in regular clinical care, public health, and research. Recognizing this, we conceived and launched an international symposium series on NGS HIVDR, to bring together leading experts in the field to address these issues through in-depth discussions and brainstorming. Following the first symposium in 2018 (Winnipeg, MB Canada, 21–22 February, 2018), a second “Winnipeg Consensus” symposium was held in September 2019 in Winnipeg, Canada, and was focused on external quality assurance strategies for NGS HIVDR assays. In this paper, we summarize this second symposium’s goals and highlights. View Full-Text
Keywords: NGS; HIV drug resistance testing; Winnipeg Consensus; symposium NGS; HIV drug resistance testing; Winnipeg Consensus; symposium
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MDPI and ACS Style

Ji, H.; Sandstrom, P.; Paredes, R.; Harrigan, P.R.; Brumme, C.J.; Avila Rios, S.; Noguera-Julian, M.; Parkin, N.; Kantor, R. Are We Ready for NGS HIV Drug Resistance Testing? The Second “Winnipeg Consensus” Symposium. Viruses 2020, 12, 586. https://doi.org/10.3390/v12060586

AMA Style

Ji H, Sandstrom P, Paredes R, Harrigan PR, Brumme CJ, Avila Rios S, Noguera-Julian M, Parkin N, Kantor R. Are We Ready for NGS HIV Drug Resistance Testing? The Second “Winnipeg Consensus” Symposium. Viruses. 2020; 12(6):586. https://doi.org/10.3390/v12060586

Chicago/Turabian Style

Ji, Hezhao, Paul Sandstrom, Roger Paredes, P. R. Harrigan, Chanson J. Brumme, Santiago Avila Rios, Marc Noguera-Julian, Neil Parkin, and Rami Kantor. 2020. "Are We Ready for NGS HIV Drug Resistance Testing? The Second “Winnipeg Consensus” Symposium" Viruses 12, no. 6: 586. https://doi.org/10.3390/v12060586

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