Next Article in Journal
Interaction between PHB2 and Enterovirus A71 VP1 Induces Autophagy and Affects EV-A71 Infection
Previous Article in Journal
The Potential of Long-Acting, Tissue-Targeted Synthetic Nanotherapy for Delivery of Antiviral Therapy Against HIV Infection
Previous Article in Special Issue
Structure-Based Design of Antivirals against Envelope Glycoprotein of Dengue Virus
Open AccessReview

New Biophysical Approaches Reveal the Dynamics and Mechanics of Type I Viral Fusion Machinery and Their Interplay with Membranes

by Mark A. Benhaim 1 and Kelly K. Lee 1,2,*
1
Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195-7610, USA
2
Biological Physics Structure and Design Program, University of Washington, Seattle, WA 98195-7610, USA
*
Author to whom correspondence should be addressed.
Viruses 2020, 12(4), 413; https://doi.org/10.3390/v12040413
Received: 11 March 2020 / Revised: 4 April 2020 / Accepted: 4 April 2020 / Published: 8 April 2020
(This article belongs to the Special Issue Mechanisms of Viral Fusion and Applications in Antivirals)
Protein-mediated membrane fusion is a highly regulated biological process essential for cellular and organismal functions and infection by enveloped viruses. During viral entry the membrane fusion reaction is catalyzed by specialized protein machinery on the viral surface. These viral fusion proteins undergo a series of dramatic structural changes during membrane fusion where they engage, remodel, and ultimately fuse with the host membrane. The structural and dynamic nature of these conformational changes and their impact on the membranes have long-eluded characterization. Recent advances in structural and biophysical methodologies have enabled researchers to directly observe viral fusion proteins as they carry out their functions during membrane fusion. Here we review the structure and function of type I viral fusion proteins and mechanisms of protein-mediated membrane fusion. We highlight how recent technological advances and new biophysical approaches are providing unprecedented new insight into the membrane fusion reaction. View Full-Text
Keywords: membrane fusion; viral fusion; type I fusion protein; influenza; hemagglutinin; dynamics; structural mechanics; biophysics; mechanisms of membrane fusion membrane fusion; viral fusion; type I fusion protein; influenza; hemagglutinin; dynamics; structural mechanics; biophysics; mechanisms of membrane fusion
Show Figures

Figure 1

MDPI and ACS Style

Benhaim, M.A.; Lee, K.K. New Biophysical Approaches Reveal the Dynamics and Mechanics of Type I Viral Fusion Machinery and Their Interplay with Membranes. Viruses 2020, 12, 413.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop