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Factors That Govern the Induction of Long-Lived Antibody Responses

Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87106, USA
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Author to whom correspondence should be addressed.
Viruses 2020, 12(1), 74; https://doi.org/10.3390/v12010074
Received: 9 December 2019 / Revised: 30 December 2019 / Accepted: 4 January 2020 / Published: 7 January 2020
(This article belongs to the Special Issue Virus-Like Particle Vaccines)
The induction of long-lasting, high-titer antibody responses is critical to the efficacy of many vaccines. The ability to produce durable antibody responses is governed by the generation of the terminally differentiated antibody-secreting B cells known as long-lived plasma cells (LLPCs). Once induced, LLPCs likely persist for decades, providing long-term protection against infection. The factors that control the generation of this important class of B cells are beginning to emerge. In particular, antigens with highly dense, multivalent structures are especially effective. Here we describe some pathogens for which the induction of long-lived antibodies is particularly important, and discuss the basis for the extraordinary ability of multivalent antigens to drive differentiation of naïve B cells to LLPCs. View Full-Text
Keywords: long-lived plasma cells; antibodies; multivalency; virus-like particles long-lived plasma cells; antibodies; multivalency; virus-like particles
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MDPI and ACS Style

Chackerian, B.; Peabody, D.S. Factors That Govern the Induction of Long-Lived Antibody Responses. Viruses 2020, 12, 74. https://doi.org/10.3390/v12010074

AMA Style

Chackerian B, Peabody DS. Factors That Govern the Induction of Long-Lived Antibody Responses. Viruses. 2020; 12(1):74. https://doi.org/10.3390/v12010074

Chicago/Turabian Style

Chackerian, Bryce, and David S. Peabody 2020. "Factors That Govern the Induction of Long-Lived Antibody Responses" Viruses 12, no. 1: 74. https://doi.org/10.3390/v12010074

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