Pediatric Infections by Human mastadenovirus C Types 2, 89, and a Recombinant Type Detected in Japan between 2011 and 2018
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patients, Clinical Data, and Adenovirus Sample Collection
2.2. Determination of Partial Sequences of Hexon Loop and Penton Base-Coding Regions
2.3. Multiplex PCR Using the Fiber Region
2.4. Virus Isolation and Neutralization
2.5. Whole Genome Sequence Analysis
2.6. Sequence Analysis
2.7. Ethical Considerations
3. Results
3.1. Adenovirus Detection and Typing by Hexon- and Fiber-Coding Regions
3.2. Nucleotide Sequencing of Penton Base- and Hexon-Coding Regions from Ad-2 Positive Samples
3.3. Complete Genome Sequences for Ad-89 and a Putatively Recombinant Ad Type
3.4. Clinical Data
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Strain * | Anti-Ad-1 | Anti-Ad-2 | Anti-Ad-5 | Anti-Ad-6 | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
5 U | 10 U | 20 U | 5 U | 10 U | 20 U | 5 U | 10 U | 20 U | 5 U | 10 U | 20 U | |
K19-085-2012 | ++++ | +++ | + | - | - | - | ++++ | +++ | + | +++ | + | ± |
K27-108-2013 | ++++ | +++ | ++ | - | - | - | ++++ | +++ | + | +++ | + | - |
K40-191-2014 | +++ | ++ | + | - | - | - | +++ | ++ | + | +++ | + | ± |
K55-255-2014 | +++ | ++ | ± | - | - | - | ++++ | +++ | + | +++ | + | ± |
K67-339-2016 | ++++ | +++ | + | - | - | - | ++++ | ++++ | ++ | +++ | + | ± |
K85-422-2017 | ++++ | +++ | + | - | - | - | ++++ | +++ | ++ | +++ | ++ | + |
Sequence | No. | Start | End | Minor Parent | Detection Method Support (p-Value) | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
RDP | GENECONV | Bootscan | Maxchi | Chimaera | SiSscan | 3Seq | |||||
K19-85 2012 | 1 | 18,725 | 21,251 | Ad-2 (J01917) | NS | 5 × 10−9 | NS | 1 × 10−2 | 1 × 10−10 | 4 × 10−12 | 1 × 10−2 |
2 | 27,376 | 31,060 | Ad-57 (HQ003817) | 2 × 10−31 | 6 × 10−101 | 9 × 10−100 | 3 × 10−36 | 2 × 10−32 | 4 × 10−54 | 3 × 10−15 | |
3 | 31,229 | 32,755 | Ad-2 (J01917) | 5 × 10−33 | 2 × 10−82 | 5 × 10−80 | 5 × 10−40 | 2 × 10−39 | 1 × 10−55 | 3 × 10−15 | |
4 | 33,123 | 34,253 | Ad-2 (J01917) | NS | 2 × 10−7 | 2 × 10−3 | 2 × 10−7 | 1 × 10−5 | 3 × 10−4 | 2 × 10−3 |
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Share and Cite
Takahashi, K.; Gonzalez, G.; Kobayashi, M.; Hanaoka, N.; Carr, M.J.; Konagaya, M.; Nojiri, N.; Ogi, M.; Fujimoto, T. Pediatric Infections by Human mastadenovirus C Types 2, 89, and a Recombinant Type Detected in Japan between 2011 and 2018. Viruses 2019, 11, 1131. https://doi.org/10.3390/v11121131
Takahashi K, Gonzalez G, Kobayashi M, Hanaoka N, Carr MJ, Konagaya M, Nojiri N, Ogi M, Fujimoto T. Pediatric Infections by Human mastadenovirus C Types 2, 89, and a Recombinant Type Detected in Japan between 2011 and 2018. Viruses. 2019; 11(12):1131. https://doi.org/10.3390/v11121131
Chicago/Turabian StyleTakahashi, Kenichiro, Gabriel Gonzalez, Masaaki Kobayashi, Nozomu Hanaoka, Michael J. Carr, Masami Konagaya, Naomi Nojiri, Miki Ogi, and Tsuguto Fujimoto. 2019. "Pediatric Infections by Human mastadenovirus C Types 2, 89, and a Recombinant Type Detected in Japan between 2011 and 2018" Viruses 11, no. 12: 1131. https://doi.org/10.3390/v11121131