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Open AccessArticle

Tissue Response to, and Degradation Rate of, Photocrosslinked Trimethylene Carbonate-Based Elastomers Following Intramuscular Implantation

1
Department of Chemical Engineering, Dupuis Hall, Queen’s University, Kingston, Ontario K7L 3N6, Canada
2
Department of Anatomy and Cell Biology, Botterell Hall, Queen's University, Kingston, Ontario K7L 3N6, Canada
*
Author to whom correspondence should be addressed.
Materials 2010, 3(2), 1156-1171; https://doi.org/10.3390/ma3021156
Received: 27 December 2009 / Revised: 4 February 2010 / Accepted: 10 February 2010 / Published: 11 February 2010
(This article belongs to the Special Issue Advances in Biomaterials)
Cylindrical elastomers were prepared through the UV-initiated crosslinking of terminally acrylated, 8,000 Da star-poly(trimethylene carbonate-co-ε-caprolactone) and star-poly(trimethylene carbonate-co-D,L-lactide). These elastomers were implanted intramuscularly into the hind legs of male Wistar rats to determine the influence of the comonomer on the weight loss, tissue response, and change in mechanical properties of the elastomer. The elastomers exhibited only a mild inflammatory response that subsided after the first week; the response was greater for the stiffer D,L-lactide-containing elastomers. The elastomers exhibited weight loss and sol content changes consistent with a bulk degradation mechanism. The D,L-lactide-containing elastomers displayed a nearly zeroorder change in Young’s modulus and stress at break over the 30 week degradation time, while the ε-caprolactone-containing elastomers exhibited little change in modulus or stress at break. View Full-Text
Keywords: in vivo; trimethylene carbonate; elastomer; lactide; caprolactone; tissue response; mechanical properties in vivo; trimethylene carbonate; elastomer; lactide; caprolactone; tissue response; mechanical properties
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Timbart, L.; Tse, M.Y.; Pang, S.C.; Amsden, B.G. Tissue Response to, and Degradation Rate of, Photocrosslinked Trimethylene Carbonate-Based Elastomers Following Intramuscular Implantation. Materials 2010, 3, 1156-1171.

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