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Article

Validation of a Homogeneous Incremental Centrifugal Liquid Sedimentation Method for Size Analysis of Silica (Nano)particles

European Commission, Joint Research Centre (JRC), 2440 Geel, Belgium
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Materials 2020, 13(17), 3806; https://doi.org/10.3390/ma13173806
Received: 29 July 2020 / Revised: 24 August 2020 / Accepted: 26 August 2020 / Published: 28 August 2020
Silica nanoparticles display many unique physicochemical properties that make them desirable for use in a wide variety of consumer products and composite materials. Accurately measuring the size of these nanoparticles is important for achieving the desired nanoscale functionality of the final product and for regulatory compliances. This study covers the validation of a centrifugal liquid sedimentation method for accurate measurement of the Stokes diameter of silica particles with a near-spherical shape and dimensions in the nanometer and sub-nanometer scale range. The validated method provided unbiased results in the range of 50 nm to 200 nm, with a lower limit of detection of ≤20 nm. The relative standard uncertainties for precision, quantified in terms of repeatability and day-to-day variation, ranged from 0.2% to 1.0% and from <0.1% to 0.5%, respectively. The standard uncertainty for trueness was assessed at 4.6%. Within its working range, the method was found robust with respect to the type of cuvette, light factor, operator, and for defining the meniscus of the sample suspension. Finally, a relative expanded measurement uncertainty of 10% confirmed the satisfactory performance of the method. View Full-Text
Keywords: centrifugal liquid sedimentation; measurement uncertainty; method validation; nanoparticles; particle size analysis; reference materials; silica centrifugal liquid sedimentation; measurement uncertainty; method validation; nanoparticles; particle size analysis; reference materials; silica
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MDPI and ACS Style

Antúnez Domínguez, J.M.; Ramaye, Y.; Dabrio, M.; Kestens, V. Validation of a Homogeneous Incremental Centrifugal Liquid Sedimentation Method for Size Analysis of Silica (Nano)particles. Materials 2020, 13, 3806. https://doi.org/10.3390/ma13173806

AMA Style

Antúnez Domínguez JM, Ramaye Y, Dabrio M, Kestens V. Validation of a Homogeneous Incremental Centrifugal Liquid Sedimentation Method for Size Analysis of Silica (Nano)particles. Materials. 2020; 13(17):3806. https://doi.org/10.3390/ma13173806

Chicago/Turabian Style

Antúnez Domínguez, Jesús Manuel, Yannic Ramaye, Marta Dabrio, and Vikram Kestens. 2020. "Validation of a Homogeneous Incremental Centrifugal Liquid Sedimentation Method for Size Analysis of Silica (Nano)particles" Materials 13, no. 17: 3806. https://doi.org/10.3390/ma13173806

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