Next Article in Journal
An Efficient Leaching of Palladium from Spent Catalysts through Oxidation with Fe(III)
Previous Article in Journal
Morphological Development of Sub-Grain Cellular/Bands Microstructures in Selective Laser Melting
Article Menu

Export Article

Open AccessArticle
Materials 2019, 12(8), 1206; https://doi.org/10.3390/ma12081206

Versatile Layer-By-Layer Highly Stable Multilayer Films: Study of the Loading and Release of FITC-Labeled Short Peptide in the Drug Delivery Field

1
Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences (Beijing), Beijing 100083, China
2
Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA
*
Authors to whom correspondence should be addressed.
Received: 7 March 2019 / Revised: 11 April 2019 / Accepted: 11 April 2019 / Published: 12 April 2019
(This article belongs to the Special Issue Advanced Materials in Drug Release and Drug Delivery Systems)
  |  
PDF [3126 KB, uploaded 12 April 2019]
  |  

Abstract

A viable short FITC-peptide immobilization is the most essential step in the fabrication of multilayer films based on FITC-peptide. These functional multilayer films have potential applications in drug delivery, medical therapy, and so forth. These FITC-peptides films needed to be handled with a lot of care and precision due to their sensitive nature. In this study, a general immobilization method is reported for the purpose of stabilizing various kinds of peptides at the interfacial regions. Utilizing Mesoporous silica nanoparticles can help in the preservation of these FITC-peptides by embedding themselves into these covalently cross-linked multilayers. This basic outlook of the multilayer films is potent enough and could be reused as a positive substrate. The spatio-temporal retention property of peptides can be modulated by varying the number of capping layers. The release speed of guest molecules such as tyrosine within FITC-peptide or/and adamantane (Ad)-in short peptides could also be fine-tuned by the specific arrangements of the multilayers of mesoporous silica nanoparticles (MSNs) and hyaluronic acid- cyclodextrin (HA-CD) multilayer films. View Full-Text
Keywords: mesoporous silica; layer-by-layer; FITC-peptide; hyaluronic acid; multilayer film; host-guest interaction mesoporous silica; layer-by-layer; FITC-peptide; hyaluronic acid; multilayer film; host-guest interaction
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Nie, K.; Yu, X.; Kumar, N.; Zhang, Y. Versatile Layer-By-Layer Highly Stable Multilayer Films: Study of the Loading and Release of FITC-Labeled Short Peptide in the Drug Delivery Field. Materials 2019, 12, 1206.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top