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Perspective

Antimicrobial Effects of Chemically Functionalized and/or Photo-Heated Nanoparticles

1
CNR-Lab. Licryl, Institute NANOTEC, 87036 Arcavacata di Rende, Italy
2
DiBEST, University of Calabria, 87036 Arcavacata di Rende, Italy
3
Department of Physics, University of Calabria, Arcavacata di Rende, 87036 Cosenza, Italy
4
Department of Medico-surgical Sciences and Biotechnologies, Sapienza University of Rome, Corso della Repubblica 79, 04100 Latina, Italy
*
Authors to whom correspondence should be addressed.
Materials 2019, 12(7), 1078; https://doi.org/10.3390/ma12071078
Received: 25 February 2019 / Revised: 26 March 2019 / Accepted: 27 March 2019 / Published: 2 April 2019
(This article belongs to the Special Issue Photothermal Therapy of Nanomaterials)
Antibiotic resistance refers to when microorganisms survive and grow in the presence of specific antibiotics, a phenomenon mainly related to the indiscriminate widespread use and abuse of antibiotics. In this framework, thanks to the design and fabrication of original functional nanomaterials, nanotechnology offers a powerful weapon against several diseases such as cancer and pathogenic illness. Smart nanomaterials, such as metallic nanoparticles and semiconductor nanocrystals, enable the realization of novel drug-free medical therapies for fighting against antibiotic-resistant bacteria. In the light of the latest developments, we highlight the outstanding capabilities of several nanotechnology-inspired approaches to kill antibiotic-resistant bacteria. Chemically functionalized silver and titanium dioxide nanoparticles have been employed for their intrinsic toxicity, which enables them to exhibit an antimicrobial activity while, in a different approach, photo-thermal properties of metallic nanoparticles have been theoretically studied and experimentally tested against several temperature sensitive (mesophilic) bacteria. We also show that it is possible to combine a highly localized targeting with a plasmonic-based heating therapy by properly functionalizing nanoparticle surfaces with covalently linked antibodies. As a perspective, the utilization of properly engineered and chemically functionalized nanomaterials opens a new roads for realizing antibiotic free treatments against pathogens and related diseases. View Full-Text
Keywords: antibacterial agents; antibiotic resistance; gold nanoparticles; plasmonic resonance; thermal inactivation antibacterial agents; antibiotic resistance; gold nanoparticles; plasmonic resonance; thermal inactivation
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MDPI and ACS Style

Pezzi, L.; Pane, A.; Annesi, F.; Losso, M.A.; Guglielmelli, A.; Umeton, C.; De Sio, L. Antimicrobial Effects of Chemically Functionalized and/or Photo-Heated Nanoparticles. Materials 2019, 12, 1078. https://doi.org/10.3390/ma12071078

AMA Style

Pezzi L, Pane A, Annesi F, Losso MA, Guglielmelli A, Umeton C, De Sio L. Antimicrobial Effects of Chemically Functionalized and/or Photo-Heated Nanoparticles. Materials. 2019; 12(7):1078. https://doi.org/10.3390/ma12071078

Chicago/Turabian Style

Pezzi, Luigia, Alfredo Pane, Ferdinanda Annesi, Maria A. Losso, Alexa Guglielmelli, Cesare Umeton, and Luciano De Sio. 2019. "Antimicrobial Effects of Chemically Functionalized and/or Photo-Heated Nanoparticles" Materials 12, no. 7: 1078. https://doi.org/10.3390/ma12071078

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