Next Article in Journal
Effects of Dislocation Density Evolution on Mechanical Behavior of OFHC Copper during High-Speed Machining
Next Article in Special Issue
Cross-Linking Strategies for Electrospun Gelatin Scaffolds
Previous Article in Journal
Synthesis of Petal-Like MnO2 Nanosheets on Hollow Fe3O4 Nanospheres for Heterogeneous Photocatalysis of Biotreated Papermaking Effluent
Previous Article in Special Issue
Injectable Scaffolds Enriched with Silver to Inhibit Bacterial Invasion in Tissue Regeneration
Open AccessFeature PaperReview

Polymer-Based Instructive Scaffolds for Endodontic Regeneration

French National Institute of Health and Medical Research (INSERM), Regenerative Nanomedicine, UMR 1260, FMTS, 67085 Strasbourg, France
Faculté de Médecine de Strasbourg, Strasbourg, Université de Strasbourg, 67000 Strasbourg, France
Pôle de Chirurgie Maxillo-Faciale et Stomatologie, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, France
Faculté de Chirurgie Dentaire de Strasbourg, Université de Strasbourg, 67000 Strasbourg, France
Hôpitaux Universitaires de Strasbourg, Pôle de Médecine et Chirurgie Bucco-Dentaires, 67000 Strasbourg, France
Author to whom correspondence should be addressed.
Materials 2019, 12(15), 2347;
Received: 9 July 2019 / Revised: 19 July 2019 / Accepted: 22 July 2019 / Published: 24 July 2019
(This article belongs to the Special Issue Polymer-based Instructive Scaffolds for Regenerative Medicine)
PDF [960 KB, uploaded 24 July 2019]


The challenge of endodontic regeneration is modulated by clinical conditions which determine five kinds of tissue requirements: pulp connective-tissue formation, dentin formation, revascularization, reinnervation and radicular edification. Polymer scaffolds constitute keystone of the different endodontic regenerative strategies. Indeed, scaffolds are crucial for carrying active molecules and competent cells which optimize the regeneration. Hydrogels are very beneficial for controlling viscosity and porosity of endodontic scaffolds. The nanofibrous and microporous scaffolds mimicking extracellular matrix are also of great interest for promoting dentin-pulp formation. Two main types of polymer scaffolds are highlighted: collagen and fibrin. Collagen scaffolds which are similar to native pulp tissue, are adequate for pulp connective tissue formation. Functionnalization by active biomolecules as BMP, SDF-1, G-CSF enhances their properties. Fibrin or PRF scaffolds present the advantage of promoting stem cell differentiation and concomitant revascularisation. The choice of the type of polymers (polypeptide, PCL, chitosan) can depend on its ability to deliver the active biomolecule or to build as suitable hydrogel as possible. Since 2010s, proposals to associate different types of polymers in a same scaffold have emerged for adding advantages or for offsetting a disadvantage of a polymer. Further works would study the synergetic effects of different innovative polymers composition. View Full-Text
Keywords: scaffolds; polymers; endodontics regeneration; dental pulp; dental stem cells; active biomolecules; hydrogels; nanofibers scaffolds; polymers; endodontics regeneration; dental pulp; dental stem cells; active biomolecules; hydrogels; nanofibers

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Zein, N.; Harmouch, E.; Lutz, J.-C.; Fernandez De Grado, G.; Kuchler-Bopp, S.; Clauss, F.; Offner, D.; Hua, G.; Benkirane-Jessel, N.; Fioretti, F. Polymer-Based Instructive Scaffolds for Endodontic Regeneration. Materials 2019, 12, 2347.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top