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Materials 2017, 10(7), 765; https://doi.org/10.3390/ma10070765

Lateral Tension-Induced Penetration of Particles into a Liposome

1
School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Nomi, Ishikawa 923-1292, Japan
2
Bio-AFM Frontier Research Center, Institute of Science and Engineering, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan
*
Authors to whom correspondence should be addressed.
Received: 8 May 2017 / Revised: 3 July 2017 / Accepted: 4 July 2017 / Published: 7 July 2017
(This article belongs to the Special Issue Constitutive Modelling of Biological Tissues and Biomaterials)
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Abstract

It is important that we understand the mechanism of the penetration of particles into a living cell to achieve advances in bionanotechnology, such as for treatment, visualization within a cell, and genetic modification. Although there have been many studies on the application of functional particles to cells, the basic mechanism of penetration across a biological membrane is still poorly understood. Here we used a model membrane system to demonstrate that lateral membrane tension drives particle penetration across a lipid bilayer. After the application of osmotic pressure, fully wrapped particles on a liposome surface were found to enter the liposome. We discuss the mechanism of the tension-induced penetration in terms of narrow constriction of the membrane at the neck part. The present findings are expected to provide insight into the application of particles to biological systems. View Full-Text
Keywords: particle penetration; lateral tension; lipid membrane; gene delivery method particle penetration; lateral tension; lipid membrane; gene delivery method
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Shigyou, K.; Nagai, K.H.; Hamada, T. Lateral Tension-Induced Penetration of Particles into a Liposome. Materials 2017, 10, 765.

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