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Open AccessArticle

Haemocompatibility of Modified Nanodiamonds

Department of Morphological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 159, 02-776 Warszawa, Poland
Department of Metrology and Optoelectronics, Faculty of Electronics, Telecommunications and Informatics, Gdańsk University of Technology, Narutowicza 11/12, 80-233 Gdańsk, Poland
Faculty of Engineering and Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat Gan 5290002, Israel
Author to whom correspondence should be addressed.
Academic Editor: Zeev Zalevsky
Materials 2017, 10(4), 352;
Received: 22 November 2016 / Revised: 21 March 2017 / Accepted: 23 March 2017 / Published: 28 March 2017
(This article belongs to the Special Issue Nanoprobes for Imaging)
This study reports the interactions of modified nanodiamond particles in vitro with human blood. Modifications performed on the nanodiamond particles include oxygenation with a chemical method and hydrogenation upon chemical vapor deposition (CVD) plasma treatment. Such nanodiamonds were later incubated in whole human blood for different time intervals, ranging from 5 min to 5 h. The morphology of red blood cells was assessed along with spectral measurements and determination of haemolysis. The results showed that no more than 3% of cells were affected by the nanodiamonds. Specific modifications of the nanodiamonds give us the possibility to obtain nanoparticles which are biocompatible with human blood. They can form a basis for the development of nanoscale biomarkers and parts of sensing systems and devices useful in biomedical environments. View Full-Text
Keywords: haemocompatibility; nanodiamonds; spectroscopy; blood; biophotonics haemocompatibility; nanodiamonds; spectroscopy; blood; biophotonics
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Wąsowicz, M.; Ficek, M.; Wróbel, M.S.; Chakraborty, R.; Fixler, D.; Wierzba, P.; Jędrzejewska-Szczerska, M. Haemocompatibility of Modified Nanodiamonds. Materials 2017, 10, 352.

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