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Open AccessArticle

In Vitro Evaluation of Dentin Tubule Occlusion for Novel Calcium Lactate Phosphate (CLP) Paste

1
Graduate Institute of Nanomedicine and Medical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11052, Taiwan
2
Center for Teeth Bank and Dental Stem Cell Technology, Taipei Medical University, Taipei 11052, Taiwan
3
School of Dentistry, Taipei Medical University, Taipei 11052, Taiwan
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Dental Department of Wan-Fang Hospital, Taipei Medical University, Taipei 11052, Taiwan
5
Graduate Institute of Biomedical Materials and Engineering, Taipei Medical University, Taipei 11052, Taiwan
6
Dental Department, Taipei Medical University Hospital, Taipei 11052, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editor: Enrico Bernardo
Materials 2017, 10(3), 228; https://doi.org/10.3390/ma10030228
Received: 19 January 2017 / Revised: 19 February 2017 / Accepted: 22 February 2017 / Published: 27 February 2017
(This article belongs to the Special Issue Bioceramics 2016)
Introduction: The objective of this in vitro study is to evaluate the effective and long-term occlusion of dentinal tubules using a novel calcium lactate phosphate (CLP) based desensitizing agent. Methods: Dentin disks (n = 9) were pre-etched using 1 M lactic acid for 30 s and individually treated with Colgate® Pro-Relief™ paste, CLP paste, and double distilled water (ddH2O) by a rubber-cupped handpiece. Dentin disks were analyzed under optical micrographs for pre-treatment, directly after treatment, and 14 days post-treatment. One-way ANOVA and post-hoc Tukey’s test were used to determine whether there were any statistically significant differences in dentinal tubule diameter. Results: A significant decrease occurred in the mean tubule diameter for dentin disks treated with CLP paste. A decrease was observed from 3.52 ± 0.83 µm to 2.62 ± 0.42 µm right after treatment, further decreasing to 1.71 ± 0.45 µm after immersion in artificial saliva for 14 days (p < 0.05). Conclusions: The results suggest that the CLP based desensitizing paste has remineralization properties and provides instant and lasting effectiveness in dentinal tubule occlusion. View Full-Text
Keywords: dentin hypersensitivity; calcium lactate phosphate (CLP); desensitizing agent dentin hypersensitivity; calcium lactate phosphate (CLP); desensitizing agent
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Yang, J.-C.; Hu, H.-T.; Lee, S.-Y.; Hsieh, S.-C.; Huang, P.-C.; Ma, C.-F.; Ji, D.-Y.; Chang, L.-Y.; Teng, N.-C. In Vitro Evaluation of Dentin Tubule Occlusion for Novel Calcium Lactate Phosphate (CLP) Paste. Materials 2017, 10, 228.

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