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Open AccessReview

Additively Manufactured Scaffolds for Bone Tissue Engineering and the Prediction of their Mechanical Behavior: A Review

by Xiang-Yu Zhang 1, Gang Fang 1,2,* and Jie Zhou 3,*
1
Department of Mechanical Engineering, Tsinghua University, Beijing 10004, China
2
State Key Laboratory of Tribology, Beijing 100084, China
3
Department of Biomechanical Engineering, Delft University of Technology, Mekelweg 2, 2628 CD Delft, The Netherlands
*
Authors to whom correspondence should be addressed.
Academic Editor: Franz Weber
Materials 2017, 10(1), 50; https://doi.org/10.3390/ma10010050
Received: 15 November 2016 / Revised: 20 December 2016 / Accepted: 22 December 2016 / Published: 10 January 2017
Additive manufacturing (AM), nowadays commonly known as 3D printing, is a revolutionary materials processing technology, particularly suitable for the production of low-volume parts with high shape complexities and often with multiple functions. As such, it holds great promise for the fabrication of patient-specific implants. In recent years, remarkable progress has been made in implementing AM in the bio-fabrication field. This paper presents an overview on the state-of-the-art AM technology for bone tissue engineering (BTE) scaffolds, with a particular focus on the AM scaffolds made of metallic biomaterials. It starts with a brief description of architecture design strategies to meet the biological and mechanical property requirements of scaffolds. Then, it summarizes the working principles, advantages and limitations of each of AM methods suitable for creating porous structures and manufacturing scaffolds from powdered materials. It elaborates on the finite-element (FE) analysis applied to predict the mechanical behavior of AM scaffolds, as well as the effect of the architectural design of porous structure on its mechanical properties. The review ends up with the authors’ view on the current challenges and further research directions. View Full-Text
Keywords: additive manufacturing; scaffold; biomaterial; geometric design; mechanical property; finite element modeling additive manufacturing; scaffold; biomaterial; geometric design; mechanical property; finite element modeling
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Zhang, X.-Y.; Fang, G.; Zhou, J. Additively Manufactured Scaffolds for Bone Tissue Engineering and the Prediction of their Mechanical Behavior: A Review. Materials 2017, 10, 50.

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