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Does the Time of Day at Which Endocrine Therapy Is Taken Affect Breast Cancer Patient Outcomes?

1
Division of Medical Oncology, Department of Medicine, University of Ottawa and the Ottawa Hospital, Ottawa, ON K1H 8L6, Canada
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Ottawa Hospital Research Institute, Ottawa, ON K1Y 4E9, Canada
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Division of Clinical Sciences, Medical Oncology, Northern Ontario School of Medicine, Thunder Bay, ON P7B 5E1, Canada
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School of Epidemiology, Public Health and Preventive Medicine, University of Ottawa, Ottawa, ON K1G 5Z3, Canada
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Ottawa Hospital, Ottawa, ON K1H 8L6, Canada
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2021, 28(4), 2523-2528; https://doi.org/10.3390/curroncol28040229
Received: 15 June 2021 / Revised: 25 June 2021 / Accepted: 4 July 2021 / Published: 6 July 2021
(This article belongs to the Section Medical Oncology)
Background: Non-compliance and non-persistence with endocrine therapy for breast cancer is common and usually related to treatment-induced side effects. There are anecdotal reports that simply changing the time of day when taking endocrine therapy (i.e., changing morning dosing to evening dosing or vice versa) can reduce side effects. Literature review: We conducted a literature review to evaluate whether changing the timing of tamoxifen and/or aromatase inhibitor administration impacted patient outcomes. No randomized control trials or prospective cohort studies that looked at time of day of endocrine therapy were identified through our review of literature from 1947 until August 2020. Conclusions: Given the rates of endocrine therapy non-compliance and non-persistence reported in the literature, ranging from 41–72% and 31–73%, respectively, simply changing the time of day when medications are taken could be an important strategy. We could identify no trials evaluating the effect of changes in timing of administration of endocrine therapy on breast cancer patient outcomes. Randomized control trials are clearly indicated for this simple and cost-effective intervention. View Full-Text
Keywords: tamoxifen; aromatase inhibitor; breast cancer; chronotherapy; side effects tamoxifen; aromatase inhibitor; breast cancer; chronotherapy; side effects
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MDPI and ACS Style

Beltran-Bless, A.-A.; Vandermeer, L.; Ibrahim, M.F.K.; Hutton, B.; Shorr, R.; Savard, M.-F.; Clemons, M. Does the Time of Day at Which Endocrine Therapy Is Taken Affect Breast Cancer Patient Outcomes? Curr. Oncol. 2021, 28, 2523-2528. https://doi.org/10.3390/curroncol28040229

AMA Style

Beltran-Bless A-A, Vandermeer L, Ibrahim MFK, Hutton B, Shorr R, Savard M-F, Clemons M. Does the Time of Day at Which Endocrine Therapy Is Taken Affect Breast Cancer Patient Outcomes? Current Oncology. 2021; 28(4):2523-2528. https://doi.org/10.3390/curroncol28040229

Chicago/Turabian Style

Beltran-Bless, Ana-Alicia, Lisa Vandermeer, Mohammed F.K. Ibrahim, Brian Hutton, Risa Shorr, Marie-France Savard, and Mark Clemons. 2021. "Does the Time of Day at Which Endocrine Therapy Is Taken Affect Breast Cancer Patient Outcomes?" Current Oncology 28, no. 4: 2523-2528. https://doi.org/10.3390/curroncol28040229

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