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Clinical Implications of “Atypia” on Biopsy: Possible Precursor to Lung Cancer?

Lung Cancer Evaluation Center at Stony Brook University Hospital, Stony Brook, NY 11790, USA
Renaissance School of Medicine at Stony Brook University, Stony Brook, NY 11790, USA
Author to whom correspondence should be addressed.
Curr. Oncol. 2021, 28(4), 2516-2522;
Received: 20 April 2021 / Revised: 29 June 2021 / Accepted: 2 July 2021 / Published: 6 July 2021
Background: It is common for biopsies of concerning pulmonary nodules to result in cytologic “atypia” on biopsy, which may represent a benign response or a false negative finding. This investigation evaluated time to diagnosis and factors which may predict an ultimate diagnosis of lung cancer in these patients with atypia cytology on lung nodule biopsy. Methods: This retrospective study included patients of the Stony Brook Lung Cancer Evaluation Center who had a biopsy baseline diagnosis of atypia between 2010 and 2020 and were either diagnosed with cancer or remained disease free by the end of the observation period. Cox Proportional Hazard (CPH) Models were used to assess factor effects on outcomes. Results: Among 106 patients with an initial diagnosis of atypia, 80 (75%) were diagnosed with lung cancer. Of those, over three-quarters were diagnosed within 6 months. The CPH models indicated that PET positivity (SUV ≥ 2.5) (HR = 1.74 (1.03, 2.94)), nodule size > 3.5 cm (HR = 2.83, 95% CI (1.47, 5.45)) and the presence of mixed ground glass opacities (HR = 2.15 (1.05, 4.43)) significantly increased risk of lung cancer. Conclusion: Given the high conversion rate to cancer within 6 months, at least tight monitoring, if not repeat biopsy may be warranted during this time period for patients diagnosed with atypia. View Full-Text
Keywords: atypia; lung cancer; lung nodule; PET; cytology atypia; lung cancer; lung nodule; PET; cytology
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MDPI and ACS Style

Albano, D.; Santore, L.A.; Bilfinger, T.; Feraca, M.; Novotny, S.; Nemesure, B. Clinical Implications of “Atypia” on Biopsy: Possible Precursor to Lung Cancer? Curr. Oncol. 2021, 28, 2516-2522.

AMA Style

Albano D, Santore LA, Bilfinger T, Feraca M, Novotny S, Nemesure B. Clinical Implications of “Atypia” on Biopsy: Possible Precursor to Lung Cancer? Current Oncology. 2021; 28(4):2516-2522.

Chicago/Turabian Style

Albano, Denise, Lee Ann Santore, Thomas Bilfinger, Melissa Feraca, Samantha Novotny, and Barbara Nemesure. 2021. "Clinical Implications of “Atypia” on Biopsy: Possible Precursor to Lung Cancer?" Current Oncology 28, no. 4: 2516-2522.

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