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Current Oncology
Volume 23
Issue 1
10.3747/co.23.2859
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Article

Management of Uveal Melanoma: A Consensus-Based Provincial Clinical Practice Guideline

by
E. Weis
1,2,*,
T.G. Salopek
3,
J.G. McKinnon
2,4,
M.P. Larocque
5,
C. Temple-Oberle
2,4,
T. Cheng
4,
J. McWhae
2,4,
R. Sloboda
5 and
M. Shea-Budgell
4,6
1
Department of Ophthalmology and Visual Sciences, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada
2
Department of Surgery, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
3
Division of Dermatology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada
4
Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
5
‖Department of Oncology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada
6
Cancer Strategic Clinical Network, Alberta Health Services, Calgary, AB, Canada
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2016, 23(1), 57-64; https://doi.org/10.3747/co.23.2859
Submission received: 5 November 2015 / Revised: 4 December 2015 / Accepted: 4 January 2016 / Published: 1 February 2016

Abstract

Introduction: Survival in uveal melanoma has remained unchanged since the early 1970s. Because outcomes are highly related to the size of the tumour, timely and accurate diagnosis can increase the chance for cure. Methods: A consensus-based guideline was developed to inform practitioners. PubMed was searched for publications related to this topic. Reference lists of key publications were hand-searched. The National Guidelines Clearinghouse and individual guideline organizations were searched for relevant guidelines. Consensus discussions by a group of content experts from medical, radiation, and surgical oncology were used to formulate the recommendations. Results: Eighty-four publications, including five existing guidelines, formed the evidence base. Summary: Key recommendations highlight that, for uveal melanoma and its indeterminate melanocytic lesions in the uveal tract, management is complex and requires experienced specialists with training in ophthalmologic oncology. Staging examinations include serum and radiologic investigations. Large lesions are still most often treated with enucleation, and yet radiotherapy is the most common treatment for tumours that qualify. Adjuvant therapy has yet to demonstrate efficacy in reducing the risk of metastasis, and no systemic therapy clearly improves outcomes in metastatic disease. Where available, enrolment in clinical trials is encouraged for patients with metastatic disease. Highly selected patients might benefit from surgical resection of liver metastases.
Keywords: Uveal melanoma; ocular melanoma; choroidal melanoma; ciliary body melanoma; iris melanoma; melanoma; ophthalmology; practice guidelines Uveal melanoma; ocular melanoma; choroidal melanoma; ciliary body melanoma; iris melanoma; melanoma; ophthalmology; practice guidelines

Share and Cite

MDPI and ACS Style

Weis, E.; Salopek, T.G.; McKinnon, J.G.; Larocque, M.P.; Temple-Oberle, C.; Cheng, T.; McWhae, J.; Sloboda, R.; Shea-Budgell, M. Management of Uveal Melanoma: A Consensus-Based Provincial Clinical Practice Guideline. Curr. Oncol. 2016, 23, 57-64. https://doi.org/10.3747/co.23.2859

AMA Style

Weis E, Salopek TG, McKinnon JG, Larocque MP, Temple-Oberle C, Cheng T, McWhae J, Sloboda R, Shea-Budgell M. Management of Uveal Melanoma: A Consensus-Based Provincial Clinical Practice Guideline. Current Oncology. 2016; 23(1):57-64. https://doi.org/10.3747/co.23.2859

Chicago/Turabian Style

Weis, E., T.G. Salopek, J.G. McKinnon, M.P. Larocque, C. Temple-Oberle, T. Cheng, J. McWhae, R. Sloboda, and M. Shea-Budgell. 2016. "Management of Uveal Melanoma: A Consensus-Based Provincial Clinical Practice Guideline" Current Oncology 23, no. 1: 57-64. https://doi.org/10.3747/co.23.2859

APA Style

Weis, E., Salopek, T. G., McKinnon, J. G., Larocque, M. P., Temple-Oberle, C., Cheng, T., McWhae, J., Sloboda, R., & Shea-Budgell, M. (2016). Management of Uveal Melanoma: A Consensus-Based Provincial Clinical Practice Guideline. Current Oncology, 23(1), 57-64. https://doi.org/10.3747/co.23.2859

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