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Current Oncology
Volume 23
Issue 1
10.3747/co.23.2780
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Short Communication

Impact of Oxaliplatin-Induced Neuropathy in Patients with Colorectal Cancer: A Prospective Evaluation at a Single Institution

by
R. Dault
1,
M.P. Rousseau
2,
A. Beaudoin
3,
M.A. Frenette
4,
F. Lemay
3 and
M.F. Beauchesne
5,*
1
Département de médecine familiale, Faculté de Médecine et des Sciences de la santé, Université de Sherbrooke, Sherbrooke, QC, Canada
2
Département de pharmacie, Centre Hospitalier Universitaire de Sherbrooke (CHUS), Sherbrooke, QC, Canada
3
CHUS, Faculté de Médecine et des Sciences de la santé (FMSS), Université de Sherbrooke, Centre de recherche du chus (CR-CHUS), Sherbrooke, QC, Canada
4
Faculté de droit, Université de Sherbrooke, Sherbrooke, QC, Canada
5
Département de pharmacie, CHUS, FMSS, Université de Sherbrooke, Faculté de pharmacie, Université de Montréal, CR-CHUS, Sherbrooke, QC, Canada
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2016, 23(1), 65-69; https://doi.org/10.3747/co.23.2780
Submission received: 11 November 2015 / Revised: 9 December 2015 / Accepted: 6 January 2016 / Published: 1 February 2016

Abstract

Oxaliplatin plays a major role in the treatment of colorectal cancer (CRC), but is associated with the development of neuropathies. The main objective of the present prospective study was to estimate the proportion of participants with grade 1, 2, 3, or 4 peripheral sensory neuropathies according to the U.S. National Cancer Institute’s Common Terminology Criteria for Adverse Events (version 4) among CRC patients treated with oxaliplatin (adjuvant or metastatic, FOLFOX or XELOX regimens) at the Centre hospitalier universitaire de Sherbrooke. Among the 57 patients so treated between May 2012 and April 2013, about 60% reported grade 2 neuropathy, at maximum, during treatment. About 25% of patients had to stop treatment because of neuropathies. In a subset of patients contacted approximately 22 months after treatment cessation, neuropathies persisted in 70%. Oxaliplatin-induced neuropathy affects a significant number of CRC patients and can influence the course of treatment and outcomes.
Keywords: Colorectal cancer; oxaliplatin; neuropathy; chemotherapy-induced peripheral neuropathy Colorectal cancer; oxaliplatin; neuropathy; chemotherapy-induced peripheral neuropathy

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MDPI and ACS Style

Dault, R.; Rousseau, M.P.; Beaudoin, A.; Frenette, M.A.; Lemay, F.; Beauchesne, M.F. Impact of Oxaliplatin-Induced Neuropathy in Patients with Colorectal Cancer: A Prospective Evaluation at a Single Institution. Curr. Oncol. 2016, 23, 65-69. https://doi.org/10.3747/co.23.2780

AMA Style

Dault R, Rousseau MP, Beaudoin A, Frenette MA, Lemay F, Beauchesne MF. Impact of Oxaliplatin-Induced Neuropathy in Patients with Colorectal Cancer: A Prospective Evaluation at a Single Institution. Current Oncology. 2016; 23(1):65-69. https://doi.org/10.3747/co.23.2780

Chicago/Turabian Style

Dault, R., M.P. Rousseau, A. Beaudoin, M.A. Frenette, F. Lemay, and M.F. Beauchesne. 2016. "Impact of Oxaliplatin-Induced Neuropathy in Patients with Colorectal Cancer: A Prospective Evaluation at a Single Institution" Current Oncology 23, no. 1: 65-69. https://doi.org/10.3747/co.23.2780

APA Style

Dault, R., Rousseau, M. P., Beaudoin, A., Frenette, M. A., Lemay, F., & Beauchesne, M. F. (2016). Impact of Oxaliplatin-Induced Neuropathy in Patients with Colorectal Cancer: A Prospective Evaluation at a Single Institution. Current Oncology, 23(1), 65-69. https://doi.org/10.3747/co.23.2780

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