Current Oncology, Volume 15, Issue 2

Questions: 1. What is the role of biochemotherapy in the treatment of metastatic malignant melanoma? 2. What are the adverse effects and effects on quality of life of biochemotherapy as a treatment option? For the purposes of this report, “biochemoth...

This new issue of Current Oncology sees a significant change of direction for the journal—for want of a better word, publication in a “hybrid format.” [...]

Methylation of DNA is known to be an important mechanism of gene regulation. A hallmark of cancer is the deregulation of the DNA methylation machinery and aberrant DNA methylation patterns 1. In vertebrate genomes, a large fraction of the CG dinucleo...

In their commentary, Drs. Takahashi and Nishibori 1 discuss putative antitumour effects of statins. [...]

Traditional Chinese Medicine (TCM) is a whole system containing therapeutic interventions that individually induce biomodulation at the physiologic, chemical, and molecular levels. The theory of TCM proposes a synergy between specific interventions s...

The use of complementary and alternative medicine is gaining popularity worldwide. Cancer patients are major consumers of natural health products for a variety of reasons; the most common is to build the body’s defense by augmenting the immune system...

Questions: (1) In patients with inoperable locally advanced or metastatic soft tissue sarcoma, does first-line doseintensive chemotherapy supported by growth factor or autologous bone marrow or stem-cell transplantation improve response rate, time to...

Chronic myeloid leukemia (CML) is a myeloproliferative disorder whose therapy has changed dramatically since the late 1990s. With the introduction of the tyrosine kinase inhibitor (TKI) imatinib mesylate, the treatment outcomes for patients with CML...

Background: Surgical margin status is an important predictor of risk of relapse among patients with rectal cancer. Methods: Patients referred to the British Columbia Cancer Agency for consideration of adjuvant therapy for rectal adenocarcinoma were i...

Since the 1960s, the incidence of malignant mesothelioma in Canada has increased dramatically because of work-related asbestos exposures. Treatment options are limited. Although chemotherapy is now an accepted standard in the management of advanced d...