Cardiovascular Medicine

5 pages, 194 KB

Open AccessEditorial

Clinical Significance of Risk Factor Assessment for the Prevention of Venous Thromboembolism

by Janine Dörffler-Melly

Cardiovasc. Med. 2006, 9(3), 94; https://doi.org/10.4414/cvm.2006.01160 - 31 Mar 2006

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Thrombosis formation is based on Virchow’s triad of vascular endothelial damage, blood flow stasis, and blood hypercoagulability. In patients with venous thromboembolism (VTE), prothrombotic states play an important pathophysiological role. They are the consequence of acquired or genetic thrombophilia, or of disorders with [...] Read more.

Thrombosis formation is based on Virchow’s triad of vascular endothelial damage, blood flow stasis, and blood hypercoagulability. In patients with venous thromboembolism (VTE), prothrombotic states play an important pathophysiological role. They are the consequence of acquired or genetic thrombophilia, or of disorders with activated coagulation or inflammation systems. Elevated levels of tissue factor (TF) carrying cell-derived microvesicles contribute to the prothrombotic state. Patients with activated inflammatory or apoptotic systems have an increased risk for VTE. Most recognised VTE risk factors are associated with a prothrombotic state. Risk factor assessment of hospitalised patients aims at identifying patients at high risk for VTE, because thromboprophylactic interventions effectively and safely prevent VTE. Specific clinical settings are associated with an increased risk for VTE, such as prior thrombosis, long distance travel, oral contraceptives, and hormone replacement therapy. Full article

1 pages, 159 KB

Open AccessEditorial

Deep Vein Thrombosis and Pulmonary Embolism

by Nils Kucher

Cardiovasc. Med. 2006, 9(3), 93; https://doi.org/10.4414/cvm.2006.01161 - 31 Mar 2006

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Abstract

Venous thromboembolism (VTE) encompasses deep vein thrombosis (DVT) and pulmonary embolism (PE)[...] Full article

3 pages, 170 KB

Open AccessCommunication

2. «Cardiovascular Roundtable» in Weggis

by Ruth Amstein, Frank Enseleit and Thomas F. Lüscher

Cardiovasc. Med. 2006, 9(3), 127; https://doi.org/10.4414/cvm.2006.01155 - 31 Mar 2006

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Abstract

Hintergrund. Traditionelle Werte und Identitäten werden in unserer schnellebigen Gesellschaft nicht nur im Gesundheitswesen, sondern in den meisten Lebensbereichen stark in Frage gestellt [...] Full article

2 pages, 446 KB

Open AccessInteresting Images

Arterielle Hypertonie und Hypotrophe Beine bei Einem 10jährigen Bub

by Gerhard Junga, Oliver Kretschmar, Walter Knirsch, Esther Fichmann and Emanuela Valsangiacomo Büchel

Cardiovasc. Med. 2006, 9(3), 125; https://doi.org/10.4414/cvm.2006.01162 - 31 Mar 2006

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Abstract

Fallbeschreibung. Ein 10jähriger Knabe wurde zur Abklärung eines Systolikums bei unauffälliger Anamnese und insbesondere uneingeschränkter körperlicher Belastbarkeit vorgestellt [...] Full article

2 pages, 217 KB

Open AccessInteresting Images

Unklares Blockbild

by Urs Bauersfeld

Cardiovasc. Med. 2006, 9(3), 123; https://doi.org/10.4414/cvm.2006.01156 - 31 Mar 2006

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Abstract

Fallbeschreibung. Ein 13jähriger Junge wird wegen Synkopen und einem Systolikum abgeklärt[...] Full article

6 pages, 243 KB

Open AccessEditorial

Therapy of Venous Thromboembolism: Anticoagulant Treatment

by Henri Bounameaux and Marc Righini

Cardiovasc. Med. 2006, 9(3), 117; https://doi.org/10.4414/cvm.2006.01158 - 31 Mar 2006

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Abstract

Treatment of acute venous thromboembolism mainly consists of administration of heparin (usually low-molecular-weight heparin) overlapped and followed by an oral vitamin K antagonist that will be administered for a certain period of time, depending upon the evaluated risk of recurrence and bleeding of [...] Read more.

Treatment of acute venous thromboembolism mainly consists of administration of heparin (usually low-molecular-weight heparin) overlapped and followed by an oral vitamin K antagonist that will be administered for a certain period of time, depending upon the evaluated risk of recurrence and bleeding of each individual patient. Contemporary features include the possibility of reducing the intensity of oral anticoagulant treatment (INR 1.5–2) after an initial full-intensity treatment (INR 2–3) period of 3 to 12 months, and the emergence of new anticoagulant drugs such as fondaparinux and ximelagatran. Full article

5 pages, 499 KB

Open AccessEditorial

Diagnostic Strategies in Deep Venous Thrombosis

by Janine Dörffler-Melly

Cardiovasc. Med. 2006, 9(3), 110; https://doi.org/10.4414/cvm.2006.01159 - 31 Mar 2006

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Abstract

The modalities to diagnose deep venous thrombosis (DVT) have improved substantially over the past decade. The contemporary diagnostic approach has shifted to an algorithm that includes the combination of clinical pre-test probability, non-invasive imaging, and D-dimer testing. Such algorithms are not only focused [...] Read more.

The modalities to diagnose deep venous thrombosis (DVT) have improved substantially over the past decade. The contemporary diagnostic approach has shifted to an algorithm that includes the combination of clinical pre-test probability, non-invasive imaging, and D-dimer testing. Such algorithms are not only focused on accurate diagnosis of DVT but on identification of low-risk patients who do not need antithrombotic therapy. This article reviews the various diagnostic tests and their incorporation into a useful diagnostic algorithm. Full article

6 pages, 119 KB

Open AccessEditorial

Prevention of Venous Thromboembolism

by Samuel Z. Goldhaber

Cardiovasc. Med. 2006, 9(3), 102; https://doi.org/10.4414/cvm.2006.01157 - 31 Mar 2006

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Abstract

Pharmacological prophylaxis should form the foundation for any prophylaxis program among hospitalised patients. For those with bleeding problems or whose risks of bleeding make this approach risky, mechanical prophylaxis should be utilised with graduated compression stockings, intermittent pneumatic compression devices, or both. For [...] Read more.

Pharmacological prophylaxis should form the foundation for any prophylaxis program among hospitalised patients. For those with bleeding problems or whose risks of bleeding make this approach risky, mechanical prophylaxis should be utilised with graduated compression stockings, intermittent pneumatic compression devices, or both. For patients at very high risk of venous thromboembolism (VTE), combined pharmacological and mechanical prophylaxis should be ordered. Failure to utilise VTE prophylaxis remains a problem in high-risk general medical and subspecialty medical patients. As part of a multifaceted approach, hospitals with adequate Information Systems should consider implementation of electronic alerts to increase deep vein thrombosis (DVT) awareness, increase use of prophylaxis, and decrease rates of DVT and pulmonary embolism. The same strategy can be instituted without any specialised computer systems, as long as a willing physician or nurse reviewer can be recruited. Within a few years, the voluntary aspects of ordering VTE prophylaxis will disappear, as regulatory authorities and insurers demand that VTE prevention becomes obligatory. Full article

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Cardiovasc. Med., Volume 9, Issue 3 (03 2006) – 8 articles

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