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Article

Defining Antibody Seroprevalence and Duration of Humoral Responses to SARS-CoV-2 Infection and/or Vaccination in a Greek Community

1
Faculty of Nursing, School of Health Sciences, University of Thessaly, Gaiopolis, 41110 Larissa, Greece
2
Department of Respiratory Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis, 41110 Larissa, Greece
3
Public Health & Vaccines Lab, Department of Nursing, School of Health Sciences, University of Thessaly, Gaiopolis, 41110 Larissa, Greece
*
Author to whom correspondence should be addressed.
Academic Editors: Riccardo Polosa, Pietro Ferrara, Luciana Albano and Venera Tomaselli
Int. J. Environ. Res. Public Health 2022, 19(1), 407; https://doi.org/10.3390/ijerph19010407
Received: 27 November 2021 / Revised: 24 December 2021 / Accepted: 28 December 2021 / Published: 31 December 2021
Background: In this work, we aimed to evaluate antibody-response longevity to SARS-CoV-2 infection and/or vaccination in one of the Greek communities that was worst hit by the pandemic, Deskati, five months after a previous serosurveillance and nine months after the pandemic wave initiation (October 2020). Methods: The SARS-CoV-2 IgG II Quant method (Architect, Abbott, IL, USA) was used for antibody testing. Results: A total of 69 subjects, who previously tested positive or negative for COVID-19 antibodies, participated in the study. We found that 48% of participants turned positive due to vaccination. 27% of participants were both previously infected and vaccinated. However, all previously infected participants retained antibodies to the virus, irrespective of their vaccination status. The antibody titers were significantly higher in previously infected participants that had been vaccinated than those who were unvaccinated and in those that had been previously hospitalized for COVID-19 than those with mild disease. Conclusions: Antibody responses to SARS-CoV-2 infection were maintained nine months after the pandemic. Vaccination alone had generated an immune response in almost half of the population. Higher antibody titers were found in the case of vaccination in previously infected subjects and especially in those with severe disease leading to hospitalization. View Full-Text
Keywords: antibody testing; Greece; semi-closed community; seroprevalence antibody testing; Greece; semi-closed community; seroprevalence
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MDPI and ACS Style

Kotsiou, O.S.; Papagiannis, D.; Fradelos, E.C.; Siachpazidou, D.I.; Perlepe, G.; Miziou, A.; Kyritsis, A.; Vavougios, G.D.; Kalantzis, G.; Gourgoulianis, K.I. Defining Antibody Seroprevalence and Duration of Humoral Responses to SARS-CoV-2 Infection and/or Vaccination in a Greek Community. Int. J. Environ. Res. Public Health 2022, 19, 407. https://doi.org/10.3390/ijerph19010407

AMA Style

Kotsiou OS, Papagiannis D, Fradelos EC, Siachpazidou DI, Perlepe G, Miziou A, Kyritsis A, Vavougios GD, Kalantzis G, Gourgoulianis KI. Defining Antibody Seroprevalence and Duration of Humoral Responses to SARS-CoV-2 Infection and/or Vaccination in a Greek Community. International Journal of Environmental Research and Public Health. 2022; 19(1):407. https://doi.org/10.3390/ijerph19010407

Chicago/Turabian Style

Kotsiou, Ourania S., Dimitrios Papagiannis, Evangelos C. Fradelos, Dimitra I. Siachpazidou, Garifallia Perlepe, Angeliki Miziou, Athanasios Kyritsis, George D. Vavougios, Georgios Kalantzis, and Konstantinos I. Gourgoulianis. 2022. "Defining Antibody Seroprevalence and Duration of Humoral Responses to SARS-CoV-2 Infection and/or Vaccination in a Greek Community" International Journal of Environmental Research and Public Health 19, no. 1: 407. https://doi.org/10.3390/ijerph19010407

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