Examination of the Effectiveness of the Healthy Empowered Active Lifestyles (HEAL) Program on Advanced Glycation End Products

Gregoski, Mathew J.; Newton, Janis; Blaylock, Kathleen; Smith, Sheila A. O.; Turner, David P.

doi:10.3390/ijerph18094863

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Examination of the Effectiveness of the Healthy Empowered Active Lifestyles (HEAL) Program on Advanced Glycation End Products

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Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA

Wellness Center, Medical University of South Carolina, Charleston, SC 29425, USA

College of Nursing, Medical University of South Carolina, Charleston, SC 29425, USA

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Department of Pathology and Laboratory Medicine, College of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA

Authors to whom correspondence should be addressed.

Academic Editors: Gregory Loyd Kinney, Krystyna Gutkowska, Dominika Głąbska and Dominika Guzek

Int. J. Environ. Res. Public Health 2021, 18(9), 4863; https://doi.org/10.3390/ijerph18094863

Received: 11 February 2021 / Revised: 26 April 2021 / Accepted: 28 April 2021 / Published: 2 May 2021

(This article belongs to the Special Issue Research on Lifestyle, Nutrition, Consumer Behavior and Family Health)

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Abstract

This pilot study investigated the effectiveness of the healthy empowered active lifestyles (HEAL) program to reduce circulatory levels of advanced glycation end products (AGEs) and assess its relationship to BMI, % body fat, fasting glucose, and A1C. The HEAL program was delivered at a local wellness center using a team-based approach and focused on physical activity and dietary education. A sample of twenty primarily European American (19 white, 1 black) participants (i.e., 10 males, 10 females) aged 26 to 71 (m = 48.75 ± 10.26) completed 12 weeks of the HEAL intervention. Pre to post changes in AGEs, BMI, % body fat, fasting glucose, and A1C were examined as primary outcomes. The findings showed participants had the following average reductions: AGEs 36.04 ± 18.48 ug/mL, BMI 2.0 ± 1.2 kg/m², % body fat 3.18 ± 1.57%, fasting glucose 5.9 ± 17.21 mg/dL, and A1C 0.68 ± 1.11%. All twenty participants successfully completed the entire twelve weeks of the HEAL intervention. The results of this study show that the HEAL intervention provides beneficial reductions of AGEs, BMI, % body fat, fasting glucose, and A1C. In addition, the high adherence shows promise, and demonstrates the potential for HEAL as a behavioral intervention to improve pre-diabetic and other inflammatory related comorbidities. Further replication of results via additional randomized controlled trials is needed. View Full-Text

Keywords: lifestyle; physicalactivity; nutrition; health; food; advanced glycation end products

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Gregoski, M.J.; Newton, J.; Blaylock, K.; Smith, S.A.O.; Turner, D.P. Examination of the Effectiveness of the Healthy Empowered Active Lifestyles (HEAL) Program on Advanced Glycation End Products. Int. J. Environ. Res. Public Health 2021, 18, 4863. https://doi.org/10.3390/ijerph18094863

AMA Style

Gregoski MJ, Newton J, Blaylock K, Smith SAO, Turner DP. Examination of the Effectiveness of the Healthy Empowered Active Lifestyles (HEAL) Program on Advanced Glycation End Products. International Journal of Environmental Research and Public Health. 2021; 18(9):4863. https://doi.org/10.3390/ijerph18094863

Chicago/Turabian Style

Gregoski, Mathew J., Janis Newton, Kathleen Blaylock, Sheila A. O. Smith, and David P. Turner. 2021. "Examination of the Effectiveness of the Healthy Empowered Active Lifestyles (HEAL) Program on Advanced Glycation End Products" International Journal of Environmental Research and Public Health 18, no. 9: 4863. https://doi.org/10.3390/ijerph18094863

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