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Open AccessArticle

Association between Chronic Interstitial Cystitis and Herpes Zoster

by Chao-Yu Hsu 1,2,3,4,5,6,7,8, Cheng-Li Lin 9,10 and Chia-Hung Kao 11,12,13,14,*
1
Department of Medical Education and Research, Puli Christian Hospital, Puli 545, Taiwan
2
Department of Family Medicine, Puli Christian Hospital, Puli 545, Taiwan
3
Department of Optometry, Central Taiwan University of Science and Technology, Taichung 40601, Taiwan
4
Center for General Education, National Taichung University of Science and Technology, Taichung 404, Taiwan
5
The General Education Center, Chaoyang University of Technology, Taichung 413, Taiwan
6
Department of General Education, National Chin-Yi University of Technology, Taichung 41170, Taiwan
7
Center for General Education, National Chi Nan University, Puli 54561, Taiwan
8
Rural Generalist Program Japan, Genepro 289-2505, Japan
9
Management Office for Health Data, China Medical University Hospital, Taichung 40447, Taiwan
10
School of Medicine, College of Medicine, China Medical University, Taichung 40447, Taiwan
11
Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40447, Taiwan
12
Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung 40447, Taiwan
13
Department of Bioinformatics and Medical Engineering, Asia University, Taichung 40447, Taiwan
14
Center of Augmented Intelligence in Healthcare, China Medical University Hospital, Taichung 40447, Taiwan
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(7), 2228; https://doi.org/10.3390/ijerph17072228 (registering DOI)
Received: 22 February 2020 / Revised: 23 March 2020 / Accepted: 24 March 2020 / Published: 26 March 2020
Objectives: Herpes zoster (HZ) infection has been associated with disease burdens such as infection and depression. However, the relationship between chronic interstitial cystitis (CIC) and HZ is unknown. This study investigated HZ risk in patients with CIC. Patients and Methods: The Longitudinal Health Insurance Database, which is a subset of the Taiwan National Health Insurance Research Database, was used in the study. The case cohort consisted of patients with newly diagnosed CIC between 2000 and 2012. Each patient with CIC was matched to four controls by age and index year. All participants were traced from the index date to HZ diagnosis, and loss to follow-up or death, or to the end of the study (31 December 2013). Results: A total of 1096 patients with CIC and 4384 controls were enrolled. The incidence rate of HZ in patients with CIC was 10.8 per 1000 person-years, whereas that for controls was 7.25 per 1000 person-years. HZ risk for the case cohort was 1.48 times that for the control cohort. Among participants aged ≤49 years, patients with CIC had a 1.91-fold-increased HZ risk compared to those without CIC. Conclusion: Patients with CIC had a higher risk of HZ than those without CIC. CIC should not be ignored, particularly in young adults.
Keywords: chronic interstitial cystitis; herpes zoster; depression chronic interstitial cystitis; herpes zoster; depression
MDPI and ACS Style

Hsu, C.-Y.; Lin, C.-L.; Kao, C.-H. Association between Chronic Interstitial Cystitis and Herpes Zoster. Int. J. Environ. Res. Public Health 2020, 17, 2228.

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