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Combined Toxicity of Nitro-Substituted Benzenes and Zinc to Photobacterium Phosphoreum: Evaluation and QSAR Analysis

1
School of Environment, and State Environmental Protection Key Laboratory of Wetland Ecology and Vegetation Restoration, Northeast Normal University, Changchun 130117, China
2
College of Geographical Sciences, Harbin Normal University, Harbin 150025, China
*
Authors to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2019, 16(6), 1041; https://doi.org/10.3390/ijerph16061041
Received: 17 February 2019 / Revised: 16 March 2019 / Accepted: 21 March 2019 / Published: 22 March 2019
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Abstract

The single toxicity (IC50) of zinc (Zn) and 11 nitro-substituted benzenes to Photobacterium phosphoreum were determined, respectively. On basis of single toxicity, the joint toxicity of binary mixtures of Zn and 11 nitro-substituted benzenes at different Zn concentrations of 0.2 IC50, 0.5 IC50, and 0.8 IC50 were measured. The joint toxicity was evaluated by toxic unit (TU) and additive index (AI) methods. The results indicated that the joint toxicity was not only depending on the Zn concentrations but also on the substituted groups of nitro-substituted benzenes. The quantitative structure-activity relation (QSAR) equations were developed and the results showed that the toxicity of nitro-substituted benzenes has different joint effect at the different Zn concentrations. At the Zn concentration of 0.2 IC50, the binary joint effects were mainly antagonism and the joint toxicity was negatively related to descriptors called VE2_B(p) and TIC3. At the Zn concentration of 0.5 IC50 and 0.8 IC50, the binary joint effects were mainly antagonism and simple addition, and the joint toxicity was related to the same descriptor Eig06_ AEA(dm). It indicated that the joint toxic actions were similar when combined at the medium and high concentrations of Zn. View Full-Text
Keywords: joint toxicity; QSAR; substituted benzenes; Photobacterium phosphoreum; zinc joint toxicity; QSAR; substituted benzenes; Photobacterium phosphoreum; zinc
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Zhang, S.; Su, L.; Zhang, X.; Li, C.; Qin, W.; Zhang, D.; Liang, X.; Zhao, Y. Combined Toxicity of Nitro-Substituted Benzenes and Zinc to Photobacterium Phosphoreum: Evaluation and QSAR Analysis. Int. J. Environ. Res. Public Health 2019, 16, 1041.

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