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Open AccessArticle

An Analysis of the Influence of Selected Genetic and Hormonal Factors on the Occurrence of Depressive Symptoms in Late-Reproductive-Age Women

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Department of Nursing, Pomeranian Medical University in Szczecin, Żołnierska Str. 48, 71-210 Szczecin, Poland
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Department of Clinical Psychology, Institute of Psychology, University of Szczecin, ul. Krakowska 71–79, 71-017 Szczecin, Poland
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Department of Psychiatry, Pomeranian Medical University in Szczecin, Broniewskiego Str. 26, 71-460 Szczecin, Poland
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Public Health Department, Pomeranian Medical University in Szczecin, Żołnierska Str. 48, 71-210 Szczecin, Poland
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Laboratory of Stem Cell Physiology and Biochemistry, Division and Department of Physiology, Pomeranian Medical University in Szczecin, Żołnierska Str. 48, 71-210 Szczecin, Poland
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Department of Nursing, Pomeranian Medical University in Szczecin, Żołnierska Str. 48, 71-210 Szczecin, Poland
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Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Int. J. Environ. Res. Public Health 2015, 12(4), 3547-3563; https://doi.org/10.3390/ijerph120403547
Received: 11 January 2015 / Revised: 18 March 2015 / Accepted: 20 March 2015 / Published: 27 March 2015
Background: The aim of this study was to analyze the influence of genetic and hormonal factors on incidences of depressive symptoms in late-reproductive-age women. Methods: The study was performed using the Beck Depression Inventory, the PCR, and genetic tests of 347 healthy late-reproductive-age Polish women. Results: The relationship between the level of anti-Müllerian hormone (AMH) and depressive symptoms was not statistically significant (p > 0.05). Increases in age and FSH levels were accompanied by a decrease in AMH level in a significant way (p < 0.05). There were no statistically significant relationships between the distribution of genotypes and the frequency of alleles of the investigated polymorphisms and depressive symptoms according to the Beck Depression Inventory. Conclusions: (1) The presence of the s/s genotype of the 5-HTTLPR polymorphism in the serotonin transporter promoter region and the 3/3 genotype of the 30-bp VNTR polymorphism in the monoamine oxidase A promoter region does not contribute to the development of depressive symptoms in late-reproductive-age women. (2) A relationship between the level of anti-Müllerian hormone and depressive symptoms was not confirmed in the group of healthy late-reproductive-age women. (3) AMH level correlates negatively with FSH level and age, which confirms that AMH can be regarded as a factor reflecting the ovarian reserve. View Full-Text
Keywords: polymorphism; AMH; FSH; late reproductive period; depressive symptoms; 5-HTTLPR; MAO-A polymorphism; AMH; FSH; late reproductive period; depressive symptoms; 5-HTTLPR; MAO-A
MDPI and ACS Style

Jurczak, A.; Szkup, M.; Samochowiec, A.; Grzywacz, A.; Samochowiec, J.; Karakiewicz, B.; Dołęgowska, B.; Grochans, E. An Analysis of the Influence of Selected Genetic and Hormonal Factors on the Occurrence of Depressive Symptoms in Late-Reproductive-Age Women. Int. J. Environ. Res. Public Health 2015, 12, 3547-3563.

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