Next Article in Journal
Toward the Synthesis and Biological Screening of a Cyclotetrapeptide from Marine Bacteria
Previous Article in Journal
Low Water Activity Induces the Production of Bioactive Metabolites in Halophilic and Halotolerant Fungi
Article Menu

Export Article

Open AccessArticle

Secondary Metabolites from a Marine-Derived Endophytic Fungus Penicillium chrysogenum QEN-24S

Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China
Graduate School of the Chinese Academy of Sciences, Yuquan Road 19A, Beijing 100049, China
Institute for Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University Duesseldorf, Universitaetsstreet 1, 40225 Duesseldorf, Germany
Author to whom correspondence should be addressed.
Mar. Drugs 2011, 9(1), 59-70;
Received: 8 November 2010 / Revised: 1 December 2010 / Accepted: 20 December 2010 / Published: 27 December 2010
PDF [225 KB, uploaded 24 February 2015]


Penicillium chrysogenum QEN-24S, an endophytic fungus isolated from an unidentified marine red algal species of the genus Laurencia, displayed inhibitory activity against the growth of pathogen Alternaria brassicae in dual culture test. Chemical investigation of this fungal strain resulted in the isolation of four new (13 and 5) and one known (4) secondary metabolites. Their structures were identified as two polyketide derivatives penicitides A and B (1 and 2), two glycerol derivatives 2-(2,4-dihydroxy-6-methylbenzoyl)-glycerol (3) and 1-(2,4-dihydroxy-6-methylbenzoyl)-glycerol (4), and one monoterpene derivative penicimonoterpene (5). Penicitides A and B (1 and 2) feature a unique 10-hydroxy- or 7,10-dihydroxy-5,7-dimethylundecyl moiety substituting at C-5 of the α-tetrahydropyrone ring, which is not reported previously among natural products. Compound 5 displayed potent activity against the pathogen A. brassicae, while compound 1 exhibited moderate cytotoxic activity against the human hepatocellular liver carcinoma cell line. View Full-Text
Keywords: marine endophyte; Penicillium chrysogenum; secondary metabolites marine endophyte; Penicillium chrysogenum; secondary metabolites

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Gao, S.-S.; Li, X.-M.; Du, F.-Y.; Li, C.-S.; Proksch, P.; Wang, B.-G. Secondary Metabolites from a Marine-Derived Endophytic Fungus Penicillium chrysogenum QEN-24S. Mar. Drugs 2011, 9, 59-70.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top