Fish Sidestream-Derived Protein Hydrolysates Suppress DSS-Induced Colitis by Modulating Intestinal Inflammation in Mice
Abstract
:1. Introduction
2. Results and Discussion
2.1. Fish-Derived Protein Hydrolysates Partly Suppress DSS-Induced Colitis Development
2.2. Nutritional Supplements Modulated Intestinal Inflammation through Cytokine and Chemokine Regulation
3. Materials and Methods
3.1. Materials
3.2. Animal Maintenance
3.3. DSS-Induced Colitis
3.4. RNA Isolation and Quantitative PCR
3.5. ELISA
3.6. Histological Analysis
3.7. Statistical Analysis
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Conflicts of Interest
References
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Supplement | Composition |
---|---|
HMB HSB HSH HMH HSH + C | Hydrolysate Mackerel Backbone |
Hydrolysate Salmon Backbone | |
Hydrolysate Salmon Heads | |
Hydrolysate Mackerel Heads | |
50% Hydrolysate Salmon Heads + 50% Collagen | |
Collagen | 100% Collagen |
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Daskalaki, M.G.; Axarlis, K.; Aspevik, T.; Orfanakis, M.; Kolliniati, O.; Lapi, I.; Tzardi, M.; Dermitzaki, E.; Venihaki, M.; Kousoulaki, K.; et al. Fish Sidestream-Derived Protein Hydrolysates Suppress DSS-Induced Colitis by Modulating Intestinal Inflammation in Mice. Mar. Drugs 2021, 19, 312. https://doi.org/10.3390/md19060312
Daskalaki MG, Axarlis K, Aspevik T, Orfanakis M, Kolliniati O, Lapi I, Tzardi M, Dermitzaki E, Venihaki M, Kousoulaki K, et al. Fish Sidestream-Derived Protein Hydrolysates Suppress DSS-Induced Colitis by Modulating Intestinal Inflammation in Mice. Marine Drugs. 2021; 19(6):312. https://doi.org/10.3390/md19060312
Chicago/Turabian StyleDaskalaki, Maria G., Konstantinos Axarlis, Tone Aspevik, Michail Orfanakis, Ourania Kolliniati, Ioanna Lapi, Maria Tzardi, Eirini Dermitzaki, Maria Venihaki, Katerina Kousoulaki, and et al. 2021. "Fish Sidestream-Derived Protein Hydrolysates Suppress DSS-Induced Colitis by Modulating Intestinal Inflammation in Mice" Marine Drugs 19, no. 6: 312. https://doi.org/10.3390/md19060312