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Brief Report

Fucoidan Supplementation Restores Fecal Lysozyme Concentrations in High-Performance Athletes: A Pilot Study

1
School of Medical Science, Griffith University, Southport, QLD 4215, Australia
2
Menzies Health Institute Queensland, Griffith University, Southport, QLD 4215, Australia
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School of Medicine, Griffith University, Southport, QLD 4215, Australia
4
Brisbane Lions Australian Football Club, Brisbane, QLD 4215, Australia
5
Marinova Pty Ltd., Cambridge, TAS 7170, Australia
*
Author to whom correspondence should be addressed.
Mar. Drugs 2020, 18(8), 412; https://doi.org/10.3390/md18080412
Received: 13 June 2020 / Revised: 30 June 2020 / Accepted: 3 August 2020 / Published: 4 August 2020
Nutritional strategies to help promote immune competence are of particular interest for a range of population groups. This study aimed to assess the potential impacts of fucoidan, a seaweed-derived bioactive polysaccharide, on gut markers of immunity and inflammation. A group of professional team-sport athletes were selected for inclusion in the study given the recognized potential for intense physical activity to induce alterations in immune function. A retrospective analysis was performed on stored fecal samples which had been collected from professional team-sport athletes (n = 22) and healthy adults (n = 11) before and after seven days of supplementation with fucoidan (Fucus vesiculosus/Undaria pinnatifida extract, 1 g/d). Fecal concentrations of calprotectin, secretory immunoglobulin A (sIgA) and lysozyme were determined using enzyme-linked immunosorbent assays. The supplement was well tolerated by participants with no adverse events reported. At baseline, fecal lysozyme concentrations were ~73% higher in the healthy adults compared to the professional athletes (p = 0.001). For the professional athletes, a significant (~45%) increase in fecal lysozyme was observed following the supplementation period (p = 0.001). These data suggest that fucoidan supplementation may have the potential to promote the secretion of antimicrobial peptides in specific population groups and contribute to the regulation of mucosal immune health. View Full-Text
Keywords: lysozyme; gut; mucosa; athletes; seaweed; fucoidan lysozyme; gut; mucosa; athletes; seaweed; fucoidan
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MDPI and ACS Style

Cox, A.J.; Cripps, A.W.; Taylor, P.A.; Fitton, J.H.; West, N.P. Fucoidan Supplementation Restores Fecal Lysozyme Concentrations in High-Performance Athletes: A Pilot Study. Mar. Drugs 2020, 18, 412. https://doi.org/10.3390/md18080412

AMA Style

Cox AJ, Cripps AW, Taylor PA, Fitton JH, West NP. Fucoidan Supplementation Restores Fecal Lysozyme Concentrations in High-Performance Athletes: A Pilot Study. Marine Drugs. 2020; 18(8):412. https://doi.org/10.3390/md18080412

Chicago/Turabian Style

Cox, Amanda J., Allan W. Cripps, Phillipa A. Taylor, J. H. Fitton, and Nicholas P. West 2020. "Fucoidan Supplementation Restores Fecal Lysozyme Concentrations in High-Performance Athletes: A Pilot Study" Marine Drugs 18, no. 8: 412. https://doi.org/10.3390/md18080412

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