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Cytotoxic Furanoditerpenes from the Sponge Spongia tubulifera Collected in the Mexican Caribbean

Centro de Investigacións Científicas Avanzadas (CICA) e Departamento de Química, Facultade de Ciencias, Universidade da Coruña, 15071 A Coruña, Spain
Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Avda. del Conocimiento 34, 18016 Granada, Spain
Universidad Autónoma de Yucatán, Campus de Ciencias Biológicas y Agropecuarias, Facultad de Medicina Veterinaria y Zootecnia, Km. 15.5 Carretera Mérida-Xmatkuil, Apdo. Postal 4-116, Itzimná Mérida, Yucatán, Mexico
Authors to whom correspondence should be addressed.
Mar. Drugs 2019, 17(7), 416;
Received: 4 July 2019 / Revised: 10 July 2019 / Accepted: 12 July 2019 / Published: 16 July 2019
PDF [1016 KB, uploaded 16 July 2019]


Two new spongian furanoditerpenes, 3β-hydroxyspongia-13(16),14-dien-2-one (1) and 19-dehydroxy-spongian diterpene 17 (2), along with five known terpenes, the spongian furanoditerpenes 9-nor-3-hydroxyspongia-3,13(16),14-trien-2-one (3), 3β,19 dihydroxyspongia-13(16),14-dien-2-one (epispongiadiol) (4) and spongian diterpene 17 (5), the furanoditerpene ambliol C (6), and the sesterterpene scalarin (7), were isolated from the methanolic extract of the sponge Spongia tubulifera, collected in the Mexican Caribbean. The planar structures of the new compounds were elucidated by 1D/2D NMR and IR spectroscopic analysis, high resolution electrospray mass spectrometry (HRESIMS), and comparison of their spectral data with those reported in the literature. Absolute configurations were determined by comparison of the experimental electronic circular dichroism (ECD) spectrum with those calculated by time-dependent density functional theory (TDDFT). Compounds 1, 4, and 6 displayed weak cytotoxic activity against different human tumour cell lines. View Full-Text
Keywords: spongian furanoditerpenes; marine sponge; Spongia tubulifera; ECD-TDDFT; cytotoxicity spongian furanoditerpenes; marine sponge; Spongia tubulifera; ECD-TDDFT; cytotoxicity

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Pech-Puch, D.; Rodríguez, J.; Cautain, B.; Sandoval-Castro, C.A.; Jiménez, C. Cytotoxic Furanoditerpenes from the Sponge Spongia tubulifera Collected in the Mexican Caribbean. Mar. Drugs 2019, 17, 416.

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