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New Antiproliferative Cembrane Diterpenes from the Red Sea Sarcophyton Species

1
Department of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt
2
School of Computing, Engineering & Physical Sciences, University of the West of Scotland, Paisley PA1 2BE, UK
3
Department of Pharmacognosy, Faculty of Pharmacy, Nahda University, Beni-Suef 62514, Egypt
4
Pharmacognosy Department, College of Pharmaceutical Sciences & Drug Manufacturing, Misr University for Science and Technology (MUST), Six October City 77, Egypt
5
Biotechnology and Life Sciences Department, Faculty of Postgraduate Studies for Advanced Sciences, Beni-Suef University, Beni-Suef 62511, Egypt
6
Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt
7
Department of Pharmaceutical Sciences, College of Pharmacy, Riyadh Elm University, Riyadh 11681, Saudi Arabia
8
Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef 62514, Egypt
9
Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha 61441, Saudi Arabia
10
Chair of Technical Biochemistry, Department of Chemistry and Food Chemsitry, Technical University of Dresden, Bergestrabe 66, Dresden 01069, Germany
11
Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia 61519, Egypt
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2019, 17(7), 411; https://doi.org/10.3390/md17070411
Received: 25 May 2019 / Revised: 28 June 2019 / Accepted: 8 July 2019 / Published: 11 July 2019
(This article belongs to the Collection Bioactive Compounds from Marine Invertebrates)
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Abstract

The combination of liquid chromatography coupled to high resolution mass spectrometry (LC-HRESMS)-based dereplication and antiproliferative activity-guided fractionation was applied on the Red Sea-derived soft coral Sarcophyton sp. This approach facilitated the isolation of five new cembrane-type diterpenoids (15), along with two known analogs (6 and 7), as well as the identification of 19 further, known compounds. The chemical structures of the new compounds were elucidated while using comprehensive spectroscopic analyses, including one-dimensional (1D) and two-dimensional (2D) NMR and HRMS. All of the isolated cembranoids (17) showed moderate in vitro antiproliferative activity against a human breast cancer cell line (MCF-7), with IC50 ranging from 22.39–27.12 µg/mL. This class of compounds could thus serve as scaffold for the future design of anticancer leads. View Full-Text
Keywords: LCHRESMS; dereplication; cembranoids; Sarcophyton; antiproliferative LCHRESMS; dereplication; cembranoids; Sarcophyton; antiproliferative
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Hassan, H.M.; Rateb, M.E.; Hassan, M.H.; Sayed, A.M.; Shabana, S.; Raslan, M.; Amin, E.; Behery, F.A.; Ahmed, O.M.; Bin Muhsinah, A.; A. M. Gulder, T.; Ramadan Abdelmohsen, U. New Antiproliferative Cembrane Diterpenes from the Red Sea Sarcophyton Species. Mar. Drugs 2019, 17, 411.

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