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Bioactive Compounds Isolated from Marine Bacterium Vibrio neocaledonicus and Their Enzyme Inhibitory Activities

1
Haikou Experimental Station, Chinese Academy of Tropical Agricultural Sciences (CATAS), Haikou 571101, China
2
Programa Ofidismo-Escorpionismo, Facultad de Ciencias Farmacéuticas y Alimentarias, Universidad de Antioquia, Medellín 1226, Colombia
3
National Center for National Products Research, School of Pharmacy, University of Mississippi, MS 38677, USA
4
Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
*
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(7), 401; https://doi.org/10.3390/md17070401
Received: 25 May 2019 / Revised: 27 June 2019 / Accepted: 2 July 2019 / Published: 8 July 2019
(This article belongs to the Special Issue Bioactive Compounds from Coral Reef Organisms)
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Abstract

Marine organisms are recognized as a source of compounds with interesting biological activities. Vibrio neocaledonicus has been reported on for its high effectiveness against corrosion in metals but it has been little studied for its chemical and biological activities. In this study, four compounds were isolated from V. neocaledonicus: indole (1); 1H-indole-3-carboxaldehyde (2); 4-hydroxybenzaldehyde (3) and Cyclo (-Pro-Tyr) (4); using a bioassay-guided method, since in a previous study it was found that the ethyl acetate extract was active on the enzymes acetylcholinesterase (AChE), alpha-glucosidase (AG) and xanthine oxidase (XO). The inhibitory activities of the three compounds against AChE, AG and XO was also evaluated. In addition, the enzymatic inhibitory activity of indole to the toxins from the venom of Bothrops asper was tested. Results showed that indole exhibited strong inhibitory activity to AG (IC50 = 18.65 ± 1.1 μM), to AChE, and XO (51.3% and 44.3% at 50 μg/mL, respectively). 1H-indole-3-carboxaldehyde displayed strong activity to XO (IC50 = 13.36 ± 0.39 μM). 4-hydroxybenzaldehyde showed moderate activity to XO (50.75% at 50 μg/mL) and weak activity to AChE (25.7% at 50 μg/mL). Furthermore, indole showed a significant in vitro inhibition to the coagulant effect induced by 1.0 μg of venom. The findings were supported by molecular docking. This is the first comprehensive report on the chemistry of V. neocaledonicus and the bioactivity of its metabolites. View Full-Text
Keywords: Vibrio neocaledonicus; acetylcholinesterase (AChE); alphaglucosidase (AG); xanthine oxidase (XO); indole; bioactive compounds; snake venom Vibrio neocaledonicus; acetylcholinesterase (AChE); alphaglucosidase (AG); xanthine oxidase (XO); indole; bioactive compounds; snake venom
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Gómez-Betancur, I.; Zhao, J.; Tan, L.; Chen, C.; Yu, G.; Rey-Suárez, P.; Preciado, L. Bioactive Compounds Isolated from Marine Bacterium Vibrio neocaledonicus and Their Enzyme Inhibitory Activities. Mar. Drugs 2019, 17, 401.

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