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Open AccessFeature PaperArticle

Extensive Tandem Duplication Events Drive the Expansion of the C1q-Domain-Containing Gene Family in Bivalves

1
Department of Life Sciences, University of Trieste, 34127 Trieste, Italy
2
National Institute of Oceanography and Applied Geophysics, 34151 Trieste, Italy
*
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(10), 583; https://doi.org/10.3390/md17100583
Received: 30 August 2019 / Revised: 11 October 2019 / Accepted: 12 October 2019 / Published: 14 October 2019
(This article belongs to the Special Issue Marine Glycobiology, Glycomics and Lectins)
C1q-domain-containing (C1qDC) proteins are rapidly emerging as key players in the innate immune response of bivalve mollusks. Growing experimental evidence suggests that these highly abundant secretory proteins are involved in the recognition of microbe-associated molecular patterns, serving as lectin-like molecules in the bivalve proto-complement system. While a large amount of functional data concerning the binding specificity of the globular head C1q domain and on the regulation of these molecules in response to infection are quickly accumulating, the genetic mechanisms that have led to the extraordinary lineage-specific expansion of the C1qDC gene family in bivalves are still largely unknown. The analysis of the chromosome-scale genome assembly of the Eastern oyster Crassostrea virginica revealed that the 476 oyster C1qDC genes, far from being uniformly distributed along the genome, are located in large clusters of tandemly duplicated paralogs, mostly found on chromosomes 7 and 8. Our observations point out that the evolutionary process behind the development of a large arsenal of C1qDC lectin-like molecules in marine bivalves is still ongoing and likely based on an unequal crossing over. View Full-Text
Keywords: innate immunity; lectins; complement system; C1q; bivalve mollusks; tandem duplication; pattern recognition receptors innate immunity; lectins; complement system; C1q; bivalve mollusks; tandem duplication; pattern recognition receptors
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Gerdol, M.; Greco, S.; Pallavicini, A. Extensive Tandem Duplication Events Drive the Expansion of the C1q-Domain-Containing Gene Family in Bivalves. Mar. Drugs 2019, 17, 583.

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