Next Article in Journal
Marine Microalgae: Promising Source for New Bioactive Compounds
Previous Article in Journal
Synthesis, Characterization, and Antifungal Property of Hydroxypropyltrimethyl Ammonium Chitosan Halogenated Acetates
Article Menu
Issue 9 (September) cover image

Export Article

Open AccessArticle
Mar. Drugs 2018, 16(9), 316; https://doi.org/10.3390/md16090316

(+)-Aeroplysinin-1 Modulates the Redox Balance of Endothelial Cells

1
Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, and IBIMA (Biomedical Research Institute of Málaga), Universidad de Málaga, Andalucía Tech, E-29071 Málaga, Spain
2
CIBER de Enfermedades Raras (CIBERER), E-29071 Málaga, Spain
Current address: Department of Pediatrics, University of Alberta, Edmonton, AB T6G 2S2, Canada.
*
Author to whom correspondence should be addressed.
Received: 22 July 2018 / Revised: 3 September 2018 / Accepted: 4 September 2018 / Published: 6 September 2018
(This article belongs to the Special Issue Halogenated Metabolites)
Full-Text   |   PDF [3574 KB, uploaded 6 September 2018]   |  

Abstract

The bioactive natural compound from marine origin, (+)-aeroplysinin-1, has been shown to exhibit potent anti-inflammatory and anti-angiogenic effects. The aim of the present study was to identify new targets for (+)-aeroplysinin-1 in endothelial cells. The sequential use of 2D-electrophoresis and MALDI-TOF-TOF/MS allowed us to identify several differentially expressed proteins. Four of these proteins were involved in redox processes and were validated by Western blot. The effects of (+)-aeroplysinin-1 were further studied by testing the effects of the treatment with this compound on the activity of several anti- and pro-oxidant enzymes, as well as on transcription factors involved in redox homeostasis. Finally, changes in the levels of total reactive oxygen species and mitochondrial membrane potential induced by endothelial cell treatments with (+)-aeroplysinin-1 were also determined. Taken altogether, these findings show that (+)-aeroplysinin-1 has multiple targets involved in endothelial cell redox regulation. View Full-Text
Keywords: aeroplysinin-1; angiogenesis; Aplysina aerophoba; endothelial cell; redox aeroplysinin-1; angiogenesis; Aplysina aerophoba; endothelial cell; redox
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

García-Vilas, J.A.; Martínez-Poveda, B.; Quesada, A.R.; Medina, M.Á. (+)-Aeroplysinin-1 Modulates the Redox Balance of Endothelial Cells. Mar. Drugs 2018, 16, 316.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top